Technology Process of 6-(benzyloxy)-2-(2-methyl-2H-[1,2,3,4]tetrazol-5-yl)-7-oxo-1,6-diazabicyclo[3.2.1]octane
There total 6 articles about 6-(benzyloxy)-2-(2-methyl-2H-[1,2,3,4]tetrazol-5-yl)-7-oxo-1,6-diazabicyclo[3.2.1]octane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
bis(trichloromethyl) carbonate; C14H20N6O;
With
triethylamine;
In
acetonitrile;
at 0 ℃;
for 0.5h;
With
dmap;
In
acetonitrile;
at 0 - 35 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine; pivaloyl chloride / dichloromethane / 1.5 h
1.2: 0.67 h / -40 °C
2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 6 h / 0 - 35 °C
3.1: sodium azide; triethylamine hydrochloride / toluene / 2 h / 100 °C
3.2: 0.25 h / 25 - 35 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 35 °C
5.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 35 °C
6.1: triethylamine / acetonitrile / 0.5 h / 0 °C
6.2: 16 h / 0 - 35 °C
With
sodium azide; pivaloyl chloride; triethylamine hydrochloride; caesium carbonate; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride;
In
dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 6 h / 0 - 35 °C
2.1: sodium azide; triethylamine hydrochloride / toluene / 2 h / 100 °C
2.2: 0.25 h / 25 - 35 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 35 °C
4.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 35 °C
5.1: triethylamine / acetonitrile / 0.5 h / 0 °C
5.2: 16 h / 0 - 35 °C
With
sodium azide; triethylamine hydrochloride; caesium carbonate; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride;
In
dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
