ETHYL 6-HYDROXYBENZO[D]ISOXAZOLE-3-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 6-HYDROXYBENZO[D]ISOXAZOLE-3-CARBOXYLATE
• CAS No.: 57764-50-8
• Molecular Formula: C10H9NO4
• Molecular Weight: 207.186
• Hs Code.: 2934999090
• Mol file: 57764-50-8.mol

Synonyms:Ethyl 6-hydroxy-1,2-benzoxazole-3-carboxylate;

Chemical Property of ETHYL 6-HYDROXYBENZO[D]ISOXAZOLE-3-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 3.58E-06mmHg at 25°C
• Refractive Index: 1.609
• Boiling Point: 375.5 °C at 760 mmHg
• Flash Point: 180.9 °C
• PSA: 72.56000
• Density: 1.359 g/cm³
• LogP: 1.71010
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl6-hydroxybenzo[d]isoxazole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 6-HYDROXYBENZO[D]ISOXAZOLE-3-CARBOXYLATE

There total 2 articles about ETHYL 6-HYDROXYBENZO[D]ISOXAZOLE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-amino-benz[d]isoxazole-3-carboxylic acid ethyl ester (932702-23-3) → 6-hydroxy-benzo[d]isoxazole-3-carboxylic acid ethyl ester (57764-50-8)

Guidance literature:

6-amino-benz[d]isoxazole-3-carboxylic acid ethyl ester; With sulfuric acid; In water; at 20 ℃; for 0.5h;

With sodium nitrite; In water; at 0 ℃; for 0.5h;

With copper(II) nitrate; copper(II) oxide; more than 3 stages;

Reference yield:

(2,4-dihydroxy-phenyl)-acetic acid ethyl ester (67828-62-0) → 6-hydroxy-benzo[d]isoxazole-3-carboxylic acid ethyl ester (57764-50-8)

Guidance literature:

With hydroxylamine-O-sulfonic acid; In water;

DOI:10.1021/ja00858a017

Reference yield: 19.0%

methyl iodide (74-88-4) + 6-hydroxy-benzo[d]isoxazole-3-carboxylic acid ethyl ester (57764-50-8) → 6-methoxy-benzo[d]isoxazole-3-carboxylic acid ethyl ester (57764-51-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

upstream raw materials:

(2,4-dihydroxy-phenyl)-acetic acid ethyl ester

6-amino-benz[d]isoxazole-3-carboxylic acid ethyl ester

Downstream raw materials:

6-methoxy-benzo[d]isoxazole-3-carboxylic acid ethyl ester

ethyl 6-(benzyloxy)-1,2-benzoxazole-3-carboxylate

6-Methoxy-3-carboxybenzisoxazol