(2S,3R)-2-tert-Butoxycarbonylamino-3-((S)-2-methylamino-3-phenyl-propionyloxy)-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

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Chemical Name:(2S,3R)-2-tert-Butoxycarbonylamino-3-((S)-2-methylamino-3-phenyl-propionyloxy)-butyric acid 2-trimethylsilanyl-ethoxymethyl ester
CAS No.:220657-15-8
Molecular Formula:C₂₅H₄₂N₂O₇Si
Molecular Weight:510.703
Hs Code.:

Synonyms:(2S,3R)-2-tert-Butoxycarbonylamino-3-((S)-2-methylamino-3-phenyl-propionyloxy)-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

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Chemical Property of (2S,3R)-2-tert-Butoxycarbonylamino-3-((S)-2-methylamino-3-phenyl-propionyloxy)-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

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Technology Process of (2S,3R)-2-tert-Butoxycarbonylamino-3-((S)-2-methylamino-3-phenyl-propionyloxy)-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

There total 6 articles about (2S,3R)-2-tert-Butoxycarbonylamino-3-((S)-2-methylamino-3-phenyl-propionyloxy)-butyric acid 2-trimethylsilanyl-ethoxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 220657-13-6
(2S,3R)-3-[(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-phenyl-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

: 220657-15-8
(2S,3R)-2-tert-Butoxycarbonylamino-3-((S)-2-methylamino-3-phenyl-propionyloxy)-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; under 760 Torr;
DOI:10.1021/ol0530023

Reference yield:

: 2899-07-2
(S)-N-benzyloxycarbonyl-N-methyl-phenyl alanine

: 220657-15-8
(2S,3R)-2-tert-Butoxycarbonylamino-3-((S)-2-methylamino-3-phenyl-propionyloxy)-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / triethylamine; 4-(dimethylamino)pyridine; isopropenyl chloroformate / CH₂Cl₂ / 1 h / 0 °C

2: 98 percent / hydrogen / Pd(OH)2 / methanol / 760.05 Torr

With dmap; Isopropenyl chloroformate; hydrogen; triethylamine; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1021/jo070412r

Reference yield:

: 126587-71-1
Boc-threonine [(2-trimethylsilyl)ethoxy]methyl ester

: 220657-15-8
(2S,3R)-2-tert-Butoxycarbonylamino-3-((S)-2-methylamino-3-phenyl-propionyloxy)-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / triethylamine; 4-(dimethylamino)pyridine; isopropenyl chloroformate / CH₂Cl₂ / 1 h / 0 °C

2: 98 percent / hydrogen / Pd(OH)2 / methanol / 760.05 Torr

With dmap; Isopropenyl chloroformate; hydrogen; triethylamine; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1021/jo070412r