(2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

Base Information

Chemical Name:(2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester
CAS No.:220657-18-1
Molecular Formula:C₄₄H₆₆N₄O₁₁Si
Molecular Weight:855.114
Hs Code.:

(2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

Synonyms:(2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

Suppliers and Price of (2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

There total 9 articles about (2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 116939-86-7
((benzyloxy)carbonyl)-L-leucyl-L-proline

: 220657-15-8
(2S,3R)-2-tert-Butoxycarbonylamino-3-((S)-2-methylamino-3-phenyl-propionyloxy)-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

: 220657-18-1
(2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

Guidance literature:: With 4-methyl-morpholine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane; at -15 - 20 ℃;
DOI:10.1021/ol0530023

Reference yield:

: 126587-71-1
Boc-threonine [(2-trimethylsilyl)ethoxy]methyl ester

: 220657-18-1
(2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / triethylamine; 4-(dimethylamino)pyridine; isopropenyl chloroformate / CH₂Cl₂ / 1 h / 0 °C

2: 98 percent / hydrogen / Pd(OH)2 / methanol / 760.05 Torr

3: 55 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride; N-methylmorpholine / CH₂Cl₂ / -15 - 20 °C

With 4-methyl-morpholine; dmap; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1021/jo070412r

Reference yield:

: 2899-07-2
(S)-N-benzyloxycarbonyl-N-methyl-phenyl alanine

: 220657-18-1
(2S,3R)-3-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-methyl-amino}-3-phenyl-propionyloxy)-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / triethylamine; 4-(dimethylamino)pyridine; isopropenyl chloroformate / CH₂Cl₂ / 1 h / 0 °C

2: 98 percent / hydrogen / Pd(OH)2 / methanol / 760.05 Torr

3: 55 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride; N-methylmorpholine / CH₂Cl₂ / -15 - 20 °C

With 4-methyl-morpholine; dmap; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1021/jo070412r