cis-4-(1-hydroxy-3-(trimethylsilyl)-2-propynyl)-3-phenoxy-1-(2-propenyl)-2-azetidinone

Base Information

Chemical Name:cis-4-(1-hydroxy-3-(trimethylsilyl)-2-propynyl)-3-phenoxy-1-(2-propenyl)-2-azetidinone
CAS No.:214477-33-5
Molecular Formula:C₁₈H₂₃NO₃Si
Molecular Weight:329.471
Hs Code.:

Synonyms:cis-4-(1-hydroxy-3-(trimethylsilyl)-2-propynyl)-3-phenoxy-1-(2-propenyl)-2-azetidinone

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Chemical Property of cis-4-(1-hydroxy-3-(trimethylsilyl)-2-propynyl)-3-phenoxy-1-(2-propenyl)-2-azetidinone

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Technology Process of cis-4-(1-hydroxy-3-(trimethylsilyl)-2-propynyl)-3-phenoxy-1-(2-propenyl)-2-azetidinone

There total 5 articles about cis-4-(1-hydroxy-3-(trimethylsilyl)-2-propynyl)-3-phenoxy-1-(2-propenyl)-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 54655-07-1
lithium trimethylsilylacetylenide

: 201748-24-5
(+)-(3R,4S)-4-formyl-3-phenoxy-1-(2-propenyl)-2-azetidinone

: 214477-33-5
cis-4-(1-hydroxy-3-(trimethylsilyl)-2-propynyl)-3-phenoxy-1-(2-propenyl)-2-azetidinone

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 0.25h;
DOI:10.1021/jo980114h

Reference yield:

: 701-99-5
Phenoxyacetyl chloride

: 214477-33-5
cis-4-(1-hydroxy-3-(trimethylsilyl)-2-propynyl)-3-phenoxy-1-(2-propenyl)-2-azetidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / Et₃N / benzene / Ambient temperature

2: p-TsOH*H₂O / tetrahydrofuran; H₂O / Heating

3: NaIO₄ / methanol; H₂O / <20 deg C

4: 96 percent / tetrahydrofuran / 0.25 h / 0 °C

With sodium periodate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; water; benzene;
DOI:10.1021/jo980114h

Reference yield:

: 358973-81-6
Allyl-[1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-amine

: 214477-33-5
cis-4-(1-hydroxy-3-(trimethylsilyl)-2-propynyl)-3-phenoxy-1-(2-propenyl)-2-azetidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / Et₃N / benzene / Ambient temperature

2: p-TsOH*H₂O / tetrahydrofuran; H₂O / Heating

3: NaIO₄ / methanol; H₂O / <20 deg C

4: 96 percent / tetrahydrofuran / 0.25 h / 0 °C

With sodium periodate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; water; benzene;
DOI:10.1021/jo980114h