methyl 2-(2-(6-chloro-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate

Base Information

• Chemical Name: methyl 2-(2-(6-chloro-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate
• CAS No.: 1394124-26-5
• Molecular Formula: C₁₇H₁₉ClN₂O₅S
• Molecular Weight: 398.867
• Mol file: 1394124-26-5.mol

Synonyms:methyl 2-(2-(6-chloro-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate

Chemical Property of methyl 2-(2-(6-chloro-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(2-(6-chloro-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate

There total 2 articles about methyl 2-(2-(6-chloro-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4,6-Dichloro-2-(methylthio)pyrimidine (6299-25-8) + 2-(2-hydroxyphenyl)-3,3-dimethoxypropionic acid methyl ester (175971-61-6) → methyl 2-(2-(6-chloro-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate (1394124-26-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 8h;

DOI:10.1002/cjoc.201200101

Reference yield:

2-Hydroxyphenylacetic acid (614-75-5) → methyl 2-(2-(6-chloro-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate (1394124-26-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 2-Methylpropionic anhydride / 10 h / 100 °C

2: methanol / 1 h / -10 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

With potassium carbonate; In methanol; 2-Methylpropionic anhydride; N,N-dimethyl-formamide;

DOI:10.1002/cjoc.201200101

Reference yield:

methyl 2-(2-(6-chloro-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate (1394124-26-5) → (E)-methyl 2-(2-(6-chloro-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate (1394124-32-3)

Guidance literature:

With methanesulfonic acid; acetic anhydride; at 90 ℃; for 2h;

DOI:10.1002/cjoc.201200101

upstream raw materials:

4,6-Dichloro-2-(methylthio)pyrimidine

2-(2-hydroxyphenyl)-3,3-dimethoxypropionic acid methyl ester

2-Hydroxyphenylacetic acid

Downstream raw materials:

(E)-methyl 2-(2-(6-chloro-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate

(E)-methyl 2-(2-(6-(2-cyanophenoxy)-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate