175971-61-6

Basic information

• Product Name: 2-(2-hydroxyphenyl)-3,3-dimethoxypropionic acid methyl ester
• Synonyms: 2-(2-hydroxyphenyl)-3,3-dimethoxypropionic acid methyl ester
• CAS NO: 175971-61-6
• Molecular Weight: 240.256
• Mol File: 175971-61-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-(2-hydroxyphenyl)-3,3-dimethoxypropionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-hydroxyphenyl)-3,3-dimethoxypropionic acid methyl ester(175971-61-6)
• EPA Substance Registry System: 2-(2-hydroxyphenyl)-3,3-dimethoxypropionic acid methyl ester(175971-61-6)

Safety Data

• Hazardous Substances Data: 175971-61-6(Hazardous Substances Data)

Upstream product

• 553-86-6 benzofuran-2(3H)-one 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 67-56-1 methanol 
• 40800-90-6 3-(α-methoxy)methylene benzofuran-2-(3H)-ketone 
• 124-41-4 sodium methylate 
• 40800-90-6 (E)-3-(α-methoxy)methylenebenzofuran-2(3H)-one 
• 614-75-5 2-Hydroxyphenylacetic acid 

Downstream Products

• 1394124-24-3 methyl 2-(2-(6-chloro-2-methylpyrimidin-4-yloxy)-phenyl)-3,3-dimethoxypropanoate 
• 1394124-25-4 methyl 2-(2-(2,6-dichloropyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate 
• 1394124-26-5 methyl 2-(2-(6-chloro-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate 
• 1394124-27-6 methyl 2-(2-(6-chloro-2-(o-tolylthio)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate 
• 1394124-31-2 (E)-methyl 2-(2-(6-chloro-2-methylpyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate 
• 114077-64-4 (E)-methyl 2-(2-(2,6-dichloropyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate 
• 1394124-32-3 (E)-methyl 2-(2-(6-chloro-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate 
• 1394124-33-4 (E)-methyl 2-(2-(6-chloro-2-(o-tolylthio)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate 
• 1394124-34-5 (E)-methyl 2-(2-(6-chloro-2-(m-tolylthio)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate 
• 1394124-35-6 (E)-methyl 2-(2-(6-chloro-2-(p-tolylthio)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate 
• 1394124-36-7 (E)-methyl 2-(2-(6-chloro-2-(pyridin-2-ylthio)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate 
• 1394124-12-9 (E)-methyl 2-(2-(6-(2-cyanophenoxy)-2-methylpyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate 
• 1394124-13-0 (E)-methyl 2-(2-(2-chloro-6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate 
• 1394124-14-1 (E)-methyl 2-(2-(6-(2-cyanophenoxy)-2-(methylthio)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate 

Relevant articles and documents

Synthesis of new strobilurin derivatives with modified 1,3,5-triazine moiety

A new procedure for the synthesis of a series of strobilurin derivatives is reported. The new compounds bear the 1,3,5-triazine ring structure and can be used as the potential fungicide. All target compounds had been identified by 1H NMR spectrum, IR spectrum and HRMS. The results of antifungal activities showed that all target compounds exhibited antifungal activities against three fungus strains at the concentration 20 μg/mL.

Synthetic method of azoxystrobin

The invention discloses a method for synthesizing azoxystrobin. The method comprises the steps: enabling 4,6-dichloropyrimidine and 2-(2-hydroxyphenyl)-3,3-dimethoxy methyl propionate to undergo coupling reaction in a proper solvent under alkaline conditions in the presence of a catalyst, so as to obtain 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxy methyl propionate; adding 2-hydroxybenzonitrile and a base or a salt of 2-hydroxybenzonitrile, and reacting, so as to obtain 2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl]-3,3-dimethoxy methyl propionate; eliminating one part of methanol, thereby obtaining azoxystrobin; or firstly, eliminating one part of methanol from 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxy methyl propionate, obtained through reaction, and then, reacting with 2-hydroxybenzonitrile and the base or the salt of 2-hydroxybenzonitrile, thereby obtaining azoxystrobin. According to the method, a newly-designed catalyst is used, and separation and after-treatment processes are simplified, so that the method is applicable to large-scale industrial production.

Method for synthesis of azoxystrobin

The invention discloses a method for synthesizing azoxystrobin and a catalyst applied to azoxystrobin synthesis. According to the catalyst, triethylene diamine is fixedly connected to the surface of silica gel, thus, the synthetic reaction of azoxystrobin can be effectively catalyzed, the catalyst can be recovered and reused by a simple method, and the consumption of the catalyst is lowered, so that the catalyst is applicable to large-scale industrial production.