7-chloro-1-ethyl-3-(2-fluoro-6-methoxyphenyl)-1,6-naphthyridin-2(1H)-one

Base Information

Chemical Name:7-chloro-1-ethyl-3-(2-fluoro-6-methoxyphenyl)-1,6-naphthyridin-2(1H)-one
CAS No.:1588424-21-8
Molecular Formula:C₁₇H₁₄ClFN₂O₂
Molecular Weight:332.762
Hs Code.:

Synonyms:7-chloro-1-ethyl-3-(2-fluoro-6-methoxyphenyl)-1,6-naphthyridin-2(1H)-one

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Chemical Property of 7-chloro-1-ethyl-3-(2-fluoro-6-methoxyphenyl)-1,6-naphthyridin-2(1H)-one

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Technology Process of 7-chloro-1-ethyl-3-(2-fluoro-6-methoxyphenyl)-1,6-naphthyridin-2(1H)-one

There total 11 articles about 7-chloro-1-ethyl-3-(2-fluoro-6-methoxyphenyl)-1,6-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1588424-20-7
7-chloro-1-ethyl-3-(2-fluoro-6-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine

: 1588424-21-8
7-chloro-1-ethyl-3-(2-fluoro-6-methoxyphenyl)-1,6-naphthyridin-2(1H)-one

Guidance literature:: 7-chloro-1-ethyl-3-(2-fluoro-6-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine; With acetic anhydride; at 120 ℃; for 2h;

With hydrogenchloride; In water; at 90 ℃; for 8h;

Reference yield:

: 40296-46-6
ethyl 4,6-dichloronicotinate

: 1588424-21-8
7-chloro-1-ethyl-3-(2-fluoro-6-methoxyphenyl)-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 16.5 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

3.1: Dess-Martin periodane / tetrahydrofuran / 5 h / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

5.1: acetic anhydride / 2 h / 120 °C

5.2: 8 h / 90 °C

With lithium aluminium tetrahydride; acetic anhydride; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 959162-97-1
6-chloro-4-ethylamino-nicotinic acid ethyl ester

: 1588424-21-8
7-chloro-1-ethyl-3-(2-fluoro-6-methoxyphenyl)-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

2.1: Dess-Martin periodane / tetrahydrofuran / 5 h / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

4.1: acetic anhydride / 2 h / 120 °C

4.2: 8 h / 90 °C

With lithium aluminium tetrahydride; acetic anhydride; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; N,N-dimethyl-formamide;