(1E)-1,1-dichloro-2-(5-(3-methoxyphenyl)-2-penten-2-yl)-2-triisopropylsilyloxycyclopropane

Base Information

Chemical Name:(1E)-1,1-dichloro-2-(5-(3-methoxyphenyl)-2-penten-2-yl)-2-triisopropylsilyloxycyclopropane
CAS No.:952315-85-4
Molecular Formula:C₂₄H₃₈Cl₂O₂Si
Molecular Weight:457.556
Hs Code.:

Synonyms:(1E)-1,1-dichloro-2-(5-(3-methoxyphenyl)-2-penten-2-yl)-2-triisopropylsilyloxycyclopropane

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Chemical Property of (1E)-1,1-dichloro-2-(5-(3-methoxyphenyl)-2-penten-2-yl)-2-triisopropylsilyloxycyclopropane

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Technology Process of (1E)-1,1-dichloro-2-(5-(3-methoxyphenyl)-2-penten-2-yl)-2-triisopropylsilyloxycyclopropane

There total 4 articles about (1E)-1,1-dichloro-2-(5-(3-methoxyphenyl)-2-penten-2-yl)-2-triisopropylsilyloxycyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 952315-77-4
(3E)-3-methyl-6-(3-methoxyphenyl)-2-triisopropylsiloxy-1,3-hexadiene

: 67-66-3,8013-54-5
chloroform

: 952315-85-4
(1E)-1,1-dichloro-2-(5-(3-methoxyphenyl)-2-penten-2-yl)-2-triisopropylsilyloxycyclopropane

Guidance literature:: With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; at 20 ℃; for 1.5h;
DOI:10.1021/ol7015669

Reference yield:

: 952315-76-3
3-methyl-6-(3-methoxyphenyl)-(3E)-hexen-2-one

: 952315-85-4
(1E)-1,1-dichloro-2-(5-(3-methoxyphenyl)-2-penten-2-yl)-2-triisopropylsilyloxycyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / triethylamine / tetrahydrofuran / 2.5 h / 0 °C

2: 88 percent / benzyltriethylammonium chloride; aq. NaOH / 1.5 h / 20 °C

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; triethylamine; In tetrahydrofuran;
DOI:10.1021/ol7015669

Reference yield:

: 7252-82-6
3-(3-methoxyphenyl)propan-1-ol

: 952315-85-4
(1E)-1,1-dichloro-2-(5-(3-methoxyphenyl)-2-penten-2-yl)-2-triisopropylsilyloxycyclopropane

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 0.25 h / -78 °C

1.2: 48 percent / CH₂Cl₂ / -78 - 20 °C

2.1: N,O-dimethylhydroxylamine hydrochloride; dimethylaluminum chloride / CH₂Cl₂ / 48 h / 20 °C

2.2: 54 percent / diethyl ether / 2 h / -78 °C

3.1: 81 percent / triethylamine / tetrahydrofuran / 2.5 h / 0 °C

4.1: 88 percent / benzyltriethylammonium chloride; aq. NaOH / 1.5 h / 20 °C

With sodium hydroxide; oxalyl dichloride; N-benzyl-N,N,N-triethylammonium chloride; N,O-dimethylhydroxylamine*hydrochloride; dimethylaluminum chloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation / 1.2: Wittig olefination;
DOI:10.1021/ol7015669