Benzyl-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butyl)-carbamic acid benzyl ester

Base Information

• Chemical Name: Benzyl-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butyl)-carbamic acid benzyl ester
• CAS No.: 866227-18-1
• Molecular Formula: C₃₆H₄₀N₄O₅
• Molecular Weight: 608.737
• Mol file: 866227-18-1.mol

Synonyms:Benzyl-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butyl)-carbamic acid benzyl ester

Chemical Property of Benzyl-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butyl)-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butyl)-carbamic acid benzyl ester

There total 7 articles about Benzyl-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(2S,3S)-3-((S)-2-Amino-3-methyl-butyrylamino)-2-hydroxy-4-phenyl-butyl]-benzyl-carbamic acid benzyl ester + 2-Picolinic acid (98-98-6) → Benzyl-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butyl)-carbamic acid benzyl ester (866227-18-1)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2005.06.048

Reference yield:

((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-benzyl-carbamic acid benzyl ester → Benzyl-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butyl)-carbamic acid benzyl ester (866227-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.19 g / N,N-diisopropylethylamine; O-(benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₄ / dimethylformamide / 20 °C

2: CF₃CO₂H / CH₂Cl₂ / 0.25 h / 20 °C

3: 0.12 g / N,N-diisopropylethylamine; O-(benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₄ / dimethylformamide / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.06.048

Reference yield:

(2S,3S)-1-[N-benzyl-N-(benzyloxycarbonyl)amino]-3-[N-(tert-butyloxycarbonyl)amino]-4-phenylbutan-2-ol (884338-61-8) → Benzyl-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butyl)-carbamic acid benzyl ester (866227-18-1)

Guidance literature:

Multi-step reaction with 4 steps

1: CF₃CO₂H / CH₂Cl₂ / 0.25 h / 20 °C

2: 0.19 g / N,N-diisopropylethylamine; O-(benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₄ / dimethylformamide / 20 °C

3: CF₃CO₂H / CH₂Cl₂ / 0.25 h / 20 °C

4: 0.12 g / N,N-diisopropylethylamine; O-(benzotriazol-1-yl)-N,N,N'N'-tetramethyluronium BF₄ / dimethylformamide / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.06.048

upstream raw materials:

2-Picolinic acid

(2S,3S)-1-[N-benzyl-N-(benzyloxycarbonyl)amino]-3-[N-(tert-butyloxycarbonyl)amino]-4-phenylbutan-2-ol

(2S,3S)-1-[N-benzyl-N-(benzyloxycarbonyl)amino]-3-[N-(tert-butyloxycarbonyl)amino]-4-phenylbutan-2-ol

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane