2-chloro-N-(6-(3-iodopropylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide

Base Information

• Chemical Name: 2-chloro-N-(6-(3-iodopropylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide
• CAS No.: 1143021-14-0
• Molecular Formula: C₂₁H₁₇ClIN₅O₄S₂
• Molecular Weight: 629.887

Synonyms:2-chloro-N-(6-(3-iodopropylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide

Chemical Property of 2-chloro-N-(6-(3-iodopropylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide

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Technology Process of 2-chloro-N-(6-(3-iodopropylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide

There total 5 articles about 2-chloro-N-(6-(3-iodopropylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxalyl dichloride (79-37-8) + 2-chloro-5-(1H-pyrazol-1-yl)benzamide (1143019-70-8) + 6-(3-iodopropylsulfonyl)benzothiazol-2-amine (1143020-47-6) → 2-chloro-N-(6-(3-iodopropylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide (1143021-14-0)

Guidance literature:

oxalyl dichloride; 2-chloro-5-(1H-pyrazol-1-yl)benzamide; In tetrahydrofuran; at 120 ℃; for 0.0833333h; Microwave irradiation;

6-(3-iodopropylsulfonyl)benzothiazol-2-amine; In tetrahydrofuran; at 120 ℃; for 0.0833333h; Microwave irradiation;

With sodium iodide; In acetone; at 65 ℃; for 16h;

Reference yield:

6-(3-iodopropylsulfonyl)benzothiazol-2-amine (1143020-47-6) + C11H7Cl2N3O2 → 2-chloro-N-(6-(3-iodopropylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide (1143021-14-0)

Guidance literature:

6-(3-iodopropylsulfonyl)benzothiazol-2-amine; C₁₁H₇Cl₂N₃O₂; In tetrahydrofuran; Microwave irradiation;

With sodium iodide; In acetone; at 65 ℃; for 16h;

DOI:10.1021/jm500610n

Reference yield:

2-chloro-5-fluorobenzamide (88487-25-6) → 2-chloro-N-(6-(3-iodopropylsulfonyl)benzothiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide (1143021-14-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: caesium carbonate / dimethyl sulfoxide / 18 h / 120 °C / Inert atmosphere

2.1: tetrahydrofuran / 0.08 h / 120 °C / Microwave irradiation

3.1: tetrahydrofuran / Microwave irradiation

3.2: 16 h / 65 °C

With caesium carbonate; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1021/jm500610n

upstream raw materials:

oxalyl dichloride

2-chloro-5-(1H-pyrazol-1-yl)benzamide

6-(3-iodopropylsulfonyl)benzothiazol-2-amine

2-chloro-5-fluorobenzamide

Downstream raw materials:

2-chloro-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide

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