2033-42-3

Basic information

• Product Name: 1-Iodo-2-naphthol
• Synonyms: 2-HYDROXY-1-IODONAPHTHALENE 97;1-iodo-2-naphtho;2-HYDROXY-1-IODONAPHTHALENE 97%;1-Iodo-2-naphthol;1-Iodo-2-hydroxynaphthalene;1-Iodonaphthalene-2-ol;1-iodonaphthalen-2-ol
• CAS NO: 2033-42-3
• Molecular Formula: C₁₀H₇IO
• Molecular Weight: 270.07
• Product Categories: Methyl Halides;API intermediates;Fused Ring Systems;Halides;Methyl Halides
• Mol File: 2033-42-3.mol
• Article Data: 55

Chemical Properties

• Melting Point: 92-96 °C(lit.)
• Boiling Point: 307 °C at 760 mmHg
• Flash Point: 139.4 °C
• Appearance: /
• Density: 1.875 g/cm³
• Vapor Pressure: 0.000412mmHg at 25°C
• Refractive Index: 1.753
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.63±0.50(Predicted)
• CAS DataBase Reference: 1-Iodo-2-naphthol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Iodo-2-naphthol(2033-42-3)
• EPA Substance Registry System: 1-Iodo-2-naphthol(2033-42-3)

Safety Data

• Hazard Codes: Xi,N
• Statements: 38-41-52/53
• Safety Statements: 26-36/37/39-61
• WGK Germany: 3
• RTECS: QL4150000
• Hazardous Substances Data: 2033-42-3(Hazardous Substances Data)

Usage

General Description

1-Iodo-2-naphthol is a chemical compound with the molecular formula C10H7IO. It is a derivative of naphthol that contains an iodo group, and is commonly used in organic synthesis as a precursor for various iodinated organic compounds. It is a white to light yellow solid that is sparingly soluble in water but more soluble in organic solvents. 1-Iodo-2-naphthol is also known for its use in the preparation of iodine-labeled biomolecules for use in nuclear medicine studies. Additionally, it has been investigated for its potential use in the treatment of certain types of cancer due to its ability to induce cell death in cancer cells. However, further research is needed to fully understand its potential applications in medicine and other fields.

InChI:InChI=1/C10H7IO/c11-10-8-4-2-1-3-7(8)5-6-9(10)12/h1-6,12H

Upstream product

• 135-19-3 β-naphthol 
• 90-15-3 α-naphthol 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 2283-08-1 2-hydroxy-1-naphthalenecarboxylic acid 
• 100424-35-9 1,1′-selenobis(naphthalen-2-ol) 
• 10034-85-2 hydrogen iodide 
• 7553-56-2 iodine 
• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 127-09-3 sodium acetate 
• 546-67-8 lead(IV) tetraacetate 
• 64-19-7 acetic acid 

Downstream Products

• 1393481-78-1 1-(3-phenylbut-1-ynyl)-2-vinyloxynaphthalene 
• 1393481-81-6 1-cyclohexylethynyl-2-vinyloxynaphthalene 
• 1393482-18-2 2-(3-phenylpropyl)-1-vinylnaphtho[2,1-b]furan 
• 1393482-21-7 2-phenyl-1-vinylnaphtho[2,1-b]furan 
• 1393482-22-8 2-(4-methoxyphenyl)-1-vinylnaphtho[2,1-b]furan 
• 1393481-48-5 1-(5-phenylpent-1-ynyl)-2-vinyloxynaphthalene 
• 1393482-27-3 3-methyl-3-phenyl-1-vinyl-3H-benzo[f]chromene 
• 1393482-29-5 3,3-pentamethylene-1-vinyl-3H-benzo[f]chromene 
• 1393482-28-4 2-cyclohexyl-1-vinylnaphtho[2,1-b]furan 
• 1393481-68-9 2-(phenylethynyl)-1-(vinyloxy)naphthalene 
• 1393481-72-5 1-(4-methoxyphenylethynyl)-2-vinyloxynaphthalene 
• 1393481-94-1 2-benzyloxy-1-hex-1-ynylnaphthalene 
• 135-19-3 β-naphthol 
• 550-60-7 1-nitro-2-naphthol 

Relevant articles and documents

An efficient domino Sonogashira/double carbopalladation/C-H-activation reaction leading to fluorescent polycyclic aromatic hydrocarbons

A facile synthesis of fluorescent polycyclic aromatic hydrocarbons through a highly productive palladium-catalyzed fourfold domino Sonogashira/double carbopalladation/C-H-activation process was developed.

Gold-Catalyzed Atroposelective Synthesis of 1,1′-Binaphthalene-2,3′-diols

A highly atroposelective (up to 97 % ee) Au-catalyzed synthesis of 1,1′-binaphthalene-2,3′-diols is reported starting from a range of substituted benzyl alkynones. Essential for the achievement of high enantioselectivity during the key assembly of the nap

Generation of Dimethyl Sulfoxide Coordinated Thermally Stable Halogen Cation Pools for C?H Halogenation

A method to generate halogen cation pools from the reaction of 1,2-dihaloethanes (hal=Br, I) and dimethyl sulfoxide (DMSO) for C?H halogenation of arenes and heteroarenes was reported. The initial reaction of DMSO and 1,2-dihaloethane generates the sulfur

Electrochemical C-H Halogenations of Enaminones and Electron-Rich Arenes with Sodium Halide (NaX) as Halogen Source for the Synthesis of 3-Halochromones and Haloarenes

Without employing an external oxidant, the simple synthesis of 3-halochromones and various halogenated electron-rich arenes has been realized with electrode oxidation by employing the simplest sodium halide (NaX, X = Cl, Br, I) as halogen source. This electrochemical method is advantageous for the simple and mild room temperature operation, environmental friendliness as well as broad substrate scope in both C-H bond donor and halogen source components.

Catalytic asymmetric construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements

An organocatalytic asymmetric process was reported for the sterically precise construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements. A series of interesting products featuring the union of a centrally chiral pyrazolone moiety and an axially chiral styrene unit were obtained in high yield with excellent diastereoselectivity and enantioselectivity (up to 99% ee, >20?:?1 dr). The process has the characteristics of mild reaction conditions, simple operation and broad substrate scope. The result of gram-scale reaction indicates that the reaction has good practicability.