N-[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-acetamide

Base Information

Chemical Name:N-[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-acetamide
CAS No.:1262858-90-1
Molecular Formula:C₁₁H₁₁BrClF₂NO₂
Molecular Weight:342.568
Hs Code.:

Synonyms:N-[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-acetamide

Chemical Property:

Purity/Quality:

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Technology Process of N-[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-acetamide

There total 1 articles about N-[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262858-89-8
2-Amino-2-(3-bromo-phenyl)-3,3-difluoro-propan-1-ol hydrochloride

: 79-04-9
chloroacetyl chloride

: 1262858-90-1
N-[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-acetamide

Guidance literature:: With sodium carbonate; In dichloromethane; water; at 0 - 20 ℃;

Reference yield:

: 1262858-90-1
N-[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-acetamide

: 1262860-79-6
5-(3-Bromo-phenyl)-5-difluoromethyl-morpholin-3-one

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; at 95 ℃; for 0.5h;

Reference yield:

: 1262858-90-1
N-[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-acetamide

: 1262858-93-4
[5-(3-Bromo-phenyl)-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / water; tert-butyl alcohol

2: P₂S₅ / pyridine

3: ammonia; methanol

4: dmap; DIPEA / quinoclamine

With dmap; P₂S₅; DIPEA; potassium tert-butylate; In pyridine; methanol; quinoclamine; ammonia; water; tert-butyl alcohol;