2-Amino-2-(3-bromo-phenyl)-3,3-difluoro-propan-1-ol hydrochloride

Base Information

• Chemical Name: 2-Amino-2-(3-bromo-phenyl)-3,3-difluoro-propan-1-ol hydrochloride
• CAS No.: 1262858-89-8
• Molecular Formula: C₉H₁₀BrF₂NO*ClH
• Molecular Weight: 302.546
• Mol file: 1262858-89-8.mol

Synonyms:2-Amino-2-(3-bromo-phenyl)-3,3-difluoro-propan-1-ol hydrochloride

Chemical Property of 2-Amino-2-(3-bromo-phenyl)-3,3-difluoro-propan-1-ol hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-Amino-2-(3-bromo-phenyl)-3,3-difluoro-propan-1-ol hydrochloride

There total 1 articles about 2-Amino-2-(3-bromo-phenyl)-3,3-difluoro-propan-1-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester (1262858-88-7) → 2-Amino-2-(3-bromo-phenyl)-3,3-difluoro-propan-1-ol hydrochloride (1262858-89-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 0.75h;

Reference yield:

2-Amino-2-(3-bromo-phenyl)-3,3-difluoro-propan-1-ol hydrochloride (1262858-89-8) + chloroacetyl chloride (79-04-9) → N-[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-acetamide (1262858-90-1)

Guidance literature:

With sodium carbonate; In dichloromethane; water; at 0 - 20 ℃;

upstream raw materials:

[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester

Downstream raw materials:

N-[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-acetamide