Technology Process of (R,S)-3-hydroxy-4-<<3-(propylamino)-3-oxopropyl>thio>-2,2-dimethyl-4-oxobutan-1-ol, phosphate ester
There total 1 articles about (R,S)-3-hydroxy-4-<<3-(propylamino)-3-oxopropyl>thio>-2,2-dimethyl-4-oxobutan-1-ol, phosphate ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 97 percent / diethyl ether / Ambient temperature
2: 94 percent / sodium methoxide / methanol / 1 h / Ambient temperature
3: 51 percent / CsF / tetrahydrofuran / 48 h
4: 87 percent / trimethylsilyl chloride, tetrabutylammonium bromide / acetonitrile / 15 h / 40 °C
With
chloro-trimethyl-silane; tetrabutylammomium bromide; sodium methylate; cesium fluoride;
In
tetrahydrofuran; methanol; diethyl ether; acetonitrile;
DOI:10.1021/jo981758s
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 56 percent / phosphopantetheine adenylyltransferase, dephosphocoenzyme A kinase, MgCl2, pyrophosphatase, pyruvate kinase, phospho(enol) pyruvate / H2O; various solvent(s) / 168 h / Ambient temperature
2: Crotalus atrox venom nucleotide pyrophosphatase EC 3.6.1.9 / H2O / 4 h
3: potato acid phosphatase EC 3.1.3.2 / H2O / 21 h
With
pyrophosphatase; pyruvate kinase; Crotalus atrox venom nucleotide pyrophosphatase EC 3.6.1.9; dephosphocoenzyme A kinase; phospho(enol) pyruvate; phosphopantetheine adenylyltransferase; potato acid phosphatase EC 3.1.3.2; magnesium chloride;
In
water;
DOI:10.1021/jo981758s
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 56 percent / phosphopantetheine adenylyltransferase, dephosphocoenzyme A kinase, MgCl2, pyrophosphatase, pyruvate kinase, phospho(enol) pyruvate / H2O; various solvent(s) / 168 h / Ambient temperature
2: Crotalus atrox venom nucleotide pyrophosphatase EC 3.6.1.9 / H2O / 4 h
3: potato acid phosphatase EC 3.1.3.2 / H2O / 21 h
4: pyridine
With
pyridine; pyrophosphatase; pyruvate kinase; Crotalus atrox venom nucleotide pyrophosphatase EC 3.6.1.9; dephosphocoenzyme A kinase; phospho(enol) pyruvate; phosphopantetheine adenylyltransferase; potato acid phosphatase EC 3.1.3.2; magnesium chloride;
In
water;
DOI:10.1021/jo981758s
