Methyl-((S)-2-phenyl-1-thiocarbamoyl-ethyl)-carbamic acid benzyl ester

Base Information

• Chemical Name: Methyl-((S)-2-phenyl-1-thiocarbamoyl-ethyl)-carbamic acid benzyl ester
• CAS No.: 386743-17-5
• Molecular Formula: C₁₈H₂₀N₂O₂S
• Molecular Weight: 328.435
• Mol file: 386743-17-5.mol

Synonyms:Methyl-((S)-2-phenyl-1-thiocarbamoyl-ethyl)-carbamic acid benzyl ester

Chemical Property of Methyl-((S)-2-phenyl-1-thiocarbamoyl-ethyl)-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Methyl-((S)-2-phenyl-1-thiocarbamoyl-ethyl)-carbamic acid benzyl ester

There total 4 articles about Methyl-((S)-2-phenyl-1-thiocarbamoyl-ethyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cbz-(NMe)Phe-NH2 (17191-53-6) → Methyl-((S)-2-phenyl-1-thiocarbamoyl-ethyl)-carbamic acid benzyl ester (386743-17-5)

Guidance literature:

With Lawessons reagent; In dichloromethane; at 20 ℃;

DOI:10.1039/b106087m

Reference yield:

(S)-N-benzyloxycarbonyl-N-methyl-phenyl alanine (2899-07-2) → Methyl-((S)-2-phenyl-1-thiocarbamoyl-ethyl)-carbamic acid benzyl ester (386743-17-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N

2: HN(TMS)2

3: Lawesson's reagent / CH₂Cl₂ / 20 °C

With Lawessons reagent; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane;

DOI:10.1039/b106087m

Reference yield:

methyl (S)-2-(benzyloxycarbonyl-methyl-amino)-3-phenylpropionate (24164-73-6) → Methyl-((S)-2-phenyl-1-thiocarbamoyl-ethyl)-carbamic acid benzyl ester (386743-17-5)

Guidance literature:

Multi-step reaction with 4 steps

1: LiOH / methanol

2: Et₃N

3: HN(TMS)2

4: Lawesson's reagent / CH₂Cl₂ / 20 °C

With Lawessons reagent; lithium hydroxide; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; dichloromethane;

DOI:10.1039/b106087m

upstream raw materials:

Cbz-(NMe)Phe-NH₂

(S)-N-benzyloxycarbonyl-N-methyl-phenyl alanine

methyl (S)-2-(benzyloxycarbonyl-methyl-amino)-3-phenylpropionate

Downstream raw materials:

(S)-N-methyl-2-phenyl-1-(thiazol-2-yl)ethanamine

(S)-N-Cbz-N-methyldolaphenine