17191-53-6

Upstream product

• 24164-73-6 methyl (S)-2-(benzyloxycarbonyl-methyl-amino)-3-phenylpropionate 
• 501-53-1 benzyl chloroformate 
• 2566-30-5 N-Methyl-L-phenylalanine 
• 2899-07-2 (S)-N-benzyloxycarbonyl-N-methyl-phenyl alanine 

Downstream Products

• 386743-16-4 (S)-N-methyl-2-phenyl-1-(thiazol-2-yl)ethanamine 
• 386743-18-6 (S)-N-Cbz-N-methyldolaphenine 
• 17193-49-6 (N-Benzyloxycarbonyl-β-O-benzyl-asp)-(N^α-methyl-phe)-amid 
• 144852-33-5 Methyl-((S)-2-phenyl-1-pyridin-2-yl-ethyl)-carbamic acid benzyl ester 
• 144852-39-1 Dimethyl-((S)-2-phenyl-1-pyridin-2-yl-ethyl)-amine 
• 144852-37-9 Methyl-((S)-2-phenyl-1-pyridin-2-yl-ethyl)-amine 
• 111540-45-5 Boc-Asp(OBzl)-(NMe)Phe-NH₂ 
• 386743-17-5 Methyl-((S)-2-phenyl-1-thiocarbamoyl-ethyl)-carbamic acid benzyl ester 
• 144852-29-9 ((S)-1-Cyano-2-phenyl-ethyl)-methyl-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of the marine natural product barbamide

The first total synthesis of the trichlorinated natural product barbamide is described. The convergent approach involves coupling (S)-3-trichloromethylbutanoyl chloride with Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione) to give 15 followed by additi

Chiral ligands containing heteroatoms; 9. General procedures for the synthesis of optically active 1-(2-pyridyl)alkylamines from α-amino acids

General syntheses of 1-(2-pyridyl)alkylamines and N-methyl or N,N-dimethyl-1-(2-pyridyl)alkylamines from optically active α-amino acids are described. The presented procedures are based on catalyzed co-cyclotrimerization of the suitable nitriles with acet

Development of Potent and Selective CCK-A Receptor Agonists from Boc-CCK-4: Tetrapeptides Containing Lys(Nε)-Amide Residues

A series of Boc-CCK-4 derivatives represented by the general structure Boc-Trp-Lys(Nε-COR)-Asp-Phe-NH2, where R is an aromatic, heterocyclic, or aliphatic group, are potent and selective CCK-A receptor agonists.These amide-bearing compounds complement the previously described urea-based tetrapeptides (Shiosaki et al.J.Med.Chem. 1991,34,2837-2842); structure-activity studies revealed parallel as well as divergent trends between these two series.A significant correlation was observed between pancreatic binding affinity and the resonance constant R of the phenyl substituent in one particular series of derivatives.Sulfation of phenolic amides appended onto the ε-amino group of the lysine did not affect affinity for the CCK-A receptor in contrast to the 500-fold increase in binding potency observed upon sulfation of CCK-8, suggesting that the lysine appendage and the sulfated tyrosine in CCK-8, both key structural elements that impart high affinity for the CCK-A receptor, are interacting differently with the receptor.The amide-bearing tetrapeptides are full agonists relative to CCK-8 in stimulating pancreatic amylase release while being partial agonists in eliciting phosphoinositide (PI) hydrolysis.Both effects were blocked by selective CCK-A receptor antagonists