Technology Process of 2-(4-(ethylsulfonyl)-2,6-difluorophenyl)acetic acid
There total 8 articles about 2-(4-(ethylsulfonyl)-2,6-difluorophenyl)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 2-(4-(ethylsulfonyl)-2,6-difluorophenyl)acetate;
With
sodium hydroxide;
In
ethanol; water;
at 20 ℃;
With
hydrogenchloride;
In
water;
pH=1;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C / Inert atmosphere
1.2: 0 - 20 °C
2.1: acetic acid; sulfuric acid / water / 100 °C
3.1: palladium on activated charcoal; hydrogen / ethanol
4.1: hydrogenchloride; sodium nitrite / water / 0.75 h / 0 °C
4.2: 45 °C
4.3: pH 1
5.1: potassium hydroxide / 20 h / Reflux
6.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
8.1: sodium hydroxide / water; ethanol / 20 °C
8.2: pH 1
With
hydrogenchloride; sulfuric acid; palladium on activated charcoal; hydrogen; sodium hydride; potassium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; sodium hydroxide; sodium nitrite;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
3.1: sodium hydroxide / water; ethanol / 20 °C
3.2: pH 1
With
potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide;
