Technology Process of 2-(2,6-difluoro-4-mercaptophenyl)acetic acid
There total 5 articles about 2-(2,6-difluoro-4-mercaptophenyl)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
for 20h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C / Inert atmosphere
1.2: 0 - 20 °C
2.1: acetic acid; sulfuric acid / water / 100 °C
3.1: palladium on activated charcoal; hydrogen / ethanol
4.1: hydrogenchloride; sodium nitrite / water / 0.75 h / 0 °C
4.2: 45 °C
4.3: pH 1
5.1: potassium hydroxide / 20 h / Reflux
With
hydrogenchloride; sulfuric acid; palladium on activated charcoal; hydrogen; sodium hydride; acetic acid; potassium hydroxide; sodium nitrite;
In
ethanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid; sulfuric acid / water / 100 °C
2.1: palladium on activated charcoal; hydrogen / ethanol
3.1: hydrogenchloride; sodium nitrite / water / 0.75 h / 0 °C
3.2: 45 °C
3.3: pH 1
4.1: potassium hydroxide / 20 h / Reflux
With
hydrogenchloride; sulfuric acid; palladium on activated charcoal; hydrogen; acetic acid; potassium hydroxide; sodium nitrite;
In
ethanol; water;
