N-[3-(2-chlorophenyl)-1-{[4-(hydroxymethyl)piperidin-1-yl]carbonyl}propyl]-1H-indole-4-sulfonamide

Base Information

Chemical Name:N-[3-(2-chlorophenyl)-1-{[4-(hydroxymethyl)piperidin-1-yl]carbonyl}propyl]-1H-indole-4-sulfonamide
CAS No.:1198056-25-5
Molecular Formula:C₂₄H₂₈ClN₃O₄S
Molecular Weight:490.023
Hs Code.:

Synonyms:N-[3-(2-chlorophenyl)-1-{[4-(hydroxymethyl)piperidin-1-yl]carbonyl}propyl]-1H-indole-4-sulfonamide

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Chemical Property of N-[3-(2-chlorophenyl)-1-{[4-(hydroxymethyl)piperidin-1-yl]carbonyl}propyl]-1H-indole-4-sulfonamide

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Technology Process of N-[3-(2-chlorophenyl)-1-{[4-(hydroxymethyl)piperidin-1-yl]carbonyl}propyl]-1H-indole-4-sulfonamide

There total 9 articles about N-[3-(2-chlorophenyl)-1-{[4-(hydroxymethyl)piperidin-1-yl]carbonyl}propyl]-1H-indole-4-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 6457-49-4
4-piperidinemethanol

: 1198055-57-0
4-(2-chlorophenyl)-2-[(1H-indol-4-ylsulfonyl)amino]butanoic acid

: 1198056-25-5
N-[3-(2-chlorophenyl)-1-{[4-(hydroxymethyl)piperidin-1-yl]carbonyl}propyl]-1H-indole-4-sulfonamide

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 4h;

Reference yield:

: 157433-36-8
3-(2-chlorophenyl)propanal

: 1198056-25-5
N-[3-(2-chlorophenyl)-1-{[4-(hydroxymethyl)piperidin-1-yl]carbonyl}propyl]-1H-indole-4-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc(II) iodide / diethyl ether / 0.25 h

1.2: 5 h / 50 °C

2.1: hydrogenchloride; water / 12 h / 100 °C

2.2: 2 h

2.3: pH 4

3.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h

3.2: 3 h

4.1: trifluoroacetic acid / dichloromethane / 1 h

4.2: 12 h

5.1: sodium hydroxide / 1,4-dioxane

5.2: pH 3

6.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h

With hydrogenchloride; dmap; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; zinc(II) iodide; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 615-41-8
2-iodochlorobenzene

: 1198056-25-5
N-[3-(2-chlorophenyl)-1-{[4-(hydroxymethyl)piperidin-1-yl]carbonyl}propyl]-1H-indole-4-sulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrabutyl-ammonium chloride; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 24 h / 30 °C / Inert atmosphere

2.1: zinc(II) iodide / diethyl ether / 0.25 h

2.2: 5 h / 50 °C

3.1: hydrogenchloride; water / 12 h / 100 °C

3.2: 2 h

3.3: pH 4

4.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h

4.2: 3 h

5.1: trifluoroacetic acid / dichloromethane / 1 h

5.2: 12 h

6.1: sodium hydroxide / 1,4-dioxane

6.2: pH 3

7.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h

With hydrogenchloride; dmap; tetrabutyl-ammonium chloride; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; palladium diacetate; zinc(II) iodide; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;