Technology Process of 4-(2-chlorophenyl)-2-[(1H-indol-4-ylsulfonyl)amino]butanoic acid
There total 7 articles about 4-(2-chlorophenyl)-2-[(1H-indol-4-ylsulfonyl)amino]butanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C19H19ClN2O4S;
With
sodium hydroxide;
In
1,4-dioxane;
With
hydrogenchloride;
In
water;
pH=3;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tetrabutyl-ammonium chloride; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 24 h / 30 °C / Inert atmosphere
2.1: zinc(II) iodide / diethyl ether / 0.25 h
2.2: 5 h / 50 °C
3.1: hydrogenchloride; water / 12 h / 100 °C
3.2: 2 h
3.3: pH 4
4.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h
4.2: 3 h
5.1: trifluoroacetic acid / dichloromethane / 1 h
5.2: 12 h
6.1: sodium hydroxide / 1,4-dioxane
6.2: pH 3
With
hydrogenchloride; dmap; tetrabutyl-ammonium chloride; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide;
palladium diacetate; zinc(II) iodide;
In
1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: zinc(II) iodide / diethyl ether / 0.25 h
1.2: 5 h / 50 °C
2.1: hydrogenchloride; water / 12 h / 100 °C
2.2: 2 h
2.3: pH 4
3.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h
3.2: 3 h
4.1: trifluoroacetic acid / dichloromethane / 1 h
4.2: 12 h
5.1: sodium hydroxide / 1,4-dioxane
5.2: pH 3
With
hydrogenchloride; dmap; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide;
zinc(II) iodide;
In
1,4-dioxane; diethyl ether; dichloromethane;
