Technology Process of ((R)-3-Benzyloxycarbonylamino-1,1,4-trioxo-1,2,3,4-tetrahydro-1λ6-benzo[b][1,4]thiazepin-5-yl)-acetic acid methyl ester
There total 7 articles about ((R)-3-Benzyloxycarbonylamino-1,1,4-trioxo-1,2,3,4-tetrahydro-1λ6-benzo[b][1,4]thiazepin-5-yl)-acetic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
Ambient temperature;
DOI:10.1021/jm00148a024
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 81 percent / aq. NaOH / Ambient temperature
2: 82 percent / NH4Cl, Zn / methanol / 1.) reflux, 4 h, 2.) RT, overnight
3: 84 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 3 h
4: 70 percent / n-Bu4NBr, KOH / tetrahydrofuran / 3 h / Ambient temperature
5: 82 percent / NaHCO3, 80percent m-chloroperoxybenzoic acid / CH2Cl2 / Ambient temperature
With
potassium hydroxide; sodium hydroxide; tetrabutylammomium bromide; sodium hydrogencarbonate; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; zinc;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00148a024
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 87 percent / 18 M aq. H2SO4 / H2O / 0.5 h / Heating
2: 81 percent / aq. NaOH / Ambient temperature
3: 82 percent / NH4Cl, Zn / methanol / 1.) reflux, 4 h, 2.) RT, overnight
4: 84 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 3 h
5: 70 percent / n-Bu4NBr, KOH / tetrahydrofuran / 3 h / Ambient temperature
6: 82 percent / NaHCO3, 80percent m-chloroperoxybenzoic acid / CH2Cl2 / Ambient temperature
With
potassium hydroxide; sodium hydroxide; sulfuric acid; tetrabutylammomium bromide; sodium hydrogencarbonate; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; zinc;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00148a024
