91088-54-9

Upstream product

• 52-90-4 L-Cysteine 
• 616-91-1 N-acetylcystein 
• 5570-19-4 2-nitrophenylboronic acid 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 94590-52-0 3(R)-amino>-5-(carbomethoxymethyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one 
• 94590-51-9 3(R)-amino>-5-(carbomethoxymethyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one 
• 94590-57-5 3(R)-[N-(1(R)-carboxy-3-phenylpropyl)amino]-5-(carboxymethyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one 
• 94590-61-1 3(R)-amino>-2,3-dihydro-1,5-benzothiazepin-4(5H)-one 
• 94590-68-8 3(R)--5-(carboxymethyl)-2,3-dihydro-1,1-dioxo-1,5-benzothiazepin-4(5H)-one hydrochloride 
• 94590-66-6 2-((R)-5-Methoxycarbonylmethyl-1,1,4-trioxo-2,3,4,5-tetrahydro-1H-1λ⁶-benzo[b][1,4]thiazepin-3-ylamino)-4-phenyl-butyric acid ethyl ester 
• 94590-33-7 (S)-2-((R)-5-Methoxycarbonylmethyl-1,4-dioxo-2,3,4,5-tetrahydro-1H-1λ⁴-benzo[b][1,4]thiazepin-3-ylamino)-4-phenyl-butyric acid ethyl ester 
• 94590-50-8 2-[(Z)-(R)-5-Methoxycarbonylmethyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylimino]-4-phenyl-butyric acid ethyl ester 
• 94590-34-8 3(R)-[N-(1(S)-carboxy-3-phenylpropyl)amino]-5-(carboxymethyl)-2,3-dihydro-1-oxo-1,5-benzothiazepin-4(5H)-one 
• 94590-67-7 ((R)-3-Benzyloxycarbonylamino-1,1,4-trioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[b][1,4]thiazepin-5-yl)-acetic acid methyl ester 
• 94590-56-4 3(R)-<(carbobenzyloxy)amino>-5-(carbomethoxymethyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one 
• 94590-53-1 S-(o-nitrophenyl)-N-(carbobenzyloxy)-L-cysteine 
• 97277-72-0 3(R)-amino>-2,3-dihydro-1,5-benzothiazepin-4(5H)-one 
• 94590-64-4 2-[(Z)-(R)-4-Oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylimino]-4-phenyl-butyric acid ethyl ester 

Relevant academic research and scientific papers

Boronic Acid Pairs for Sequential Bioconjugation

Boronic acids can play diverse roles when applied in biological environments, and employing boronic acid structures in tandem could provide new tools for multifunctional probes. This Letter describes a pair of boronic acid functional groups, 2-nitro-arylboronic acid (NAB) and (E)-alkenylboronic acid (EAB), that enable sequential cross-coupling through stepwise nickel- and copper-catalyzed processes. The selective coupling of NAB groups enables the preparation of stapled peptides, protein-protein conjugates, and other bioconjugates.

S-Aryl cysteine S,S-dioxides as inhibitors of mammalian kynureninase

A series of 2-amino-S-aryl cysteine S,S-dioxides have been synthesised and shown to inhibit kynureninase an important enzyme in the biosynthesis of the known excitotoxic moiety quinolinic acid. The most potent of these, 2-amino-5-methyl-S-phenyl cysteine S,S-dioxide 6d, inhibits interferon-γ induced synthesis of quinolinic acid in human macrophages.

Angiotensin converting enzyme inhibitors: 1,5-Benzothiazepine derivatives

The synthesis of chiral 1,5-benzothiazepines 2a-c, 14a-c, 15c, and 16a prepared from cysteine is described. In vitro inhibition of angiotensin converting enzyme (ACE) is reported for each compound. Compound 2c was the most potent in vitro having an ICsub