5'-O-benzoylribothymidine dialdehyde

Base Information

• Chemical Name: 5'-O-benzoylribothymidine dialdehyde
• CAS No.: 130515-49-0
• Molecular Formula: C₁₇H₁₆N₂O₇
• Molecular Weight: 360.323
• Mol file: 130515-49-0.mol

Synonyms:5'-O-benzoylribothymidine dialdehyde

Chemical Property of 5'-O-benzoylribothymidine dialdehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-benzoylribothymidine dialdehyde

There total 4 articles about 5'-O-benzoylribothymidine dialdehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(5-O-benzoyl-β-D-ribofuranosyl)thymine (120649-55-0) → 5'-O-benzoylribothymidine dialdehyde (130515-49-0)

Guidance literature:

With sodium periodate; In ethanol; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85449-1

Reference yield:

5-Methyluridine (1463-10-1,642082-80-2) → 5'-O-benzoylribothymidine dialdehyde (130515-49-0)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(II) sulfate; sulfuric acid / 24 h / 15 °C / Large scale

2: pyridine / 5 h / 15 °C / Large scale

3: water; trifluoroacetic acid / 10 h / 15 °C / Large scale

4: sodium periodate / ethanol; water / 2 h / 15 °C / Darkness

With pyridine; sodium periodate; sulfuric acid; water; copper(II) sulfate; trifluoroacetic acid; In ethanol; water;

Reference yield:

2',3'-O,O-isopropylidene-5-methyluridine (2073-43-0) → 5'-O-benzoylribothymidine dialdehyde (130515-49-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 5 h / 15 °C / Large scale

2: water; trifluoroacetic acid / 10 h / 15 °C / Large scale

3: sodium periodate / ethanol; water / 2 h / 15 °C / Darkness

With pyridine; sodium periodate; water; trifluoroacetic acid; In ethanol; water;

upstream raw materials:

1-(5-O-benzoyl-β-D-ribofuranosyl)thymine

5-Methyluridine

2',3'-O,O-isopropylidene-5-methyluridine

5'-O-benzoyl-2',3'-O-isopropylidene-5-methyluridine

Downstream raw materials:

3'-Azido-2',3'-dideoxy-2',3'-secothymidine

5'-O-benzoyl-2'-deoxy-3'-O-mesyl-2',3'-secothymidine

3'-Azido-5'-O-benzoyl-2',3'-dideoxy-2',3'-secothymidine

Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[(R)-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-ethoxy]-propyl ester