N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>-N-methyl-L-phenylalanine tert-butyl ester

Base Information

Chemical Name:N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>-N-methyl-L-phenylalanine tert-butyl ester
CAS No.:120711-15-1
Molecular Formula:C₃₂H₃₆N₂O₅
Molecular Weight:528.648
Hs Code.:

Synonyms:N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>-N-methyl-L-phenylalanine tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>-N-methyl-L-phenylalanine tert-butyl ester

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Technology Process of N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>-N-methyl-L-phenylalanine tert-butyl ester

There total 6 articles about N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>-N-methyl-L-phenylalanine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 120711-14-0
(E)-3-[((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-methyl-carbamoyl]-4-phenyl-but-3-enoic acid

: 120711-15-1
N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>-N-methyl-L-phenylalanine tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; 1.) 0 deg C, 1 h, 2.) r.t., overnight;
DOI:10.1021/jm00127a017

Reference yield:

: 2899-07-2
(S)-N-benzyloxycarbonyl-N-methyl-phenyl alanine

: 120711-15-1
N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>-N-methyl-L-phenylalanine tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: benzene / 0.5 h / Heating

2: hydrogen / 10 percent Pd/charcoal / methanol / 5 h / Ambient temperature

3: 100 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / 1.) 0 deg C, 1 h, 2.) r.t., overnight

4: 49.5 percent / 1 M NaOH / ethanol; H₂O / 1.) 0 deg C, 1 h, 2.) r.t., 5 h

5: 31 percent / triethylamine, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / 1.) 0 deg C, 1 h, 2.) r.t., overnight

With sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; water; benzene;
DOI:10.1021/jm00127a017

Reference yield:

: 114525-93-8
Cbz-(Me)Phe-Ot-Bu

: 120711-15-1
N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>-N-methyl-L-phenylalanine tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 10 percent Pd/charcoal / methanol / 5 h / Ambient temperature

2: 100 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / 1.) 0 deg C, 1 h, 2.) r.t., overnight

3: 49.5 percent / 1 M NaOH / ethanol; H₂O / 1.) 0 deg C, 1 h, 2.) r.t., 5 h

4: 31 percent / triethylamine, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / 1.) 0 deg C, 1 h, 2.) r.t., overnight

With sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; water;
DOI:10.1021/jm00127a017