4-Chloro-N,N-dimethylbenzenepropanamide

Base Information

Chemical Name:4-Chloro-N,N-dimethylbenzenepropanamide
CAS No.:72457-30-8
Molecular Formula:C₁₁H₁₄ClNO
Molecular Weight:211.691
Hs Code.:
DSSTox Substance ID:DTXSID601278492

Synonyms:72457-30-8;N,N-Dimethyl-3-(4-chlorophenyl)-propanamide;4-Chloro-N,N-dimethylbenzenepropanamide;SCHEMBL11132861;DTXSID601278492;MFCD11778049;AKOS033668813;3-(4-chlorophenyl)-N,N-dimethylpropanamide;Z192626986

Suppliers and Price of 4-Chloro-N,N-dimethylbenzenepropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Chloro-N,N-dimethylbenzenepropanamide

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:211.0763918
Heavy Atom Count:14
Complexity:186

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)C(=O)CCC1=CC=C(C=C1)Cl

Technology Process of 4-Chloro-N,N-dimethylbenzenepropanamide

There total 8 articles about 4-Chloro-N,N-dimethylbenzenepropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 127-19-5,116057-81-9
N,N-dimethyl acetamide

: 873-76-7
para-Chlorobenzyl alcohol

: 72457-30-8
N,N-dimethyl-3-(4-chlorophenyl)propionamide

Guidance literature:: With Ru(η(2)-2-(2'-pyridyl)phenyl)Cl(CO)(PPh3)2; potassium tert-butylate; In toluene; at 80 ℃; for 6h; Inert atmosphere; Schlenk technique; Green chemistry;
DOI:10.1002/cctc.201901319

Reference yield: 79.0%

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 201230-82-2
carbon monoxide

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 72457-30-8
N,N-dimethyl-3-(4-chlorophenyl)propionamide

: 1949-36-6
2-(4-chlorophenyl)-N,N-dimethylpropanamide

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); N-methyl-2-pyrrolidone hydrochloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; at 120 ℃; for 24h; under 7600.51 Torr; Autoclave;
DOI:10.1021/acs.orglett.8b00538

Reference yield: 48.0%

: 127-19-5,116057-81-9
N,N-dimethyl acetamide

: (4-chlorophenyl)methan-d2-ol-d

: 72457-30-8
N,N-dimethyl-3-(4-chlorophenyl)propionamide

: C₁₁H₁₂⁽²⁾H₂ClNO

Guidance literature:: With C₁₅H₂₅Cl₂N₃NiO₃; potassium tert-butylate; In octane; at 110 ℃; Overall yield = 28 %; Inert atmosphere;
DOI:10.1002/cssc.201801443