Ethyl 1-(3-(4-phenyl-phenylmethyl)-4-chromanon-7-yl)cyclopentane-carboxylate

Base Information

• Chemical Name: Ethyl 1-(3-(4-phenyl-phenylmethyl)-4-chromanon-7-yl)cyclopentane-carboxylate
• CAS No.: 179107-64-3
• Molecular Formula: C₃₀H₃₀O₄
• Molecular Weight: 454.566
• Mol file: 179107-64-3.mol

Synonyms:Ethyl 1-(3-(4-phenyl-phenylmethyl)-4-chromanon-7-yl)cyclopentane-carboxylate

Chemical Property of Ethyl 1-(3-(4-phenyl-phenylmethyl)-4-chromanon-7-yl)cyclopentane-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 1-(3-(4-phenyl-phenylmethyl)-4-chromanon-7-yl)cyclopentane-carboxylate

There total 5 articles about Ethyl 1-(3-(4-phenyl-phenylmethyl)-4-chromanon-7-yl)cyclopentane-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(Cyclopentylidene-ethoxy-methoxy)-trimethyl-silane + Trifluoro-methanesulfonic acid 3-biphenyl-4-ylmethyl-4-oxo-chroman-7-yl ester (179107-69-8) → Ethyl 1-(3-(4-phenyl-phenylmethyl)-4-chromanon-7-yl)cyclopentane-carboxylate (179107-64-3)

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; tris-(o-tolyl)phosphine; zinc(II) chloride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1021/jm00046a001

Reference yield:

4-Phenylbenzaldehyde (3218-36-8) → Ethyl 1-(3-(4-phenyl-phenylmethyl)-4-chromanon-7-yl)cyclopentane-carboxylate (179107-64-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyrrolidine / methanol / Ambient temperature

2: H₂ / 10percent Pd/C / ethyl acetate / 2068.6 Torr

3: 87 percent / Pd(PhCN)2Cl₂, ZnCl₂, P(o-tol)3 / dimethylformamide; 1,2-dimethoxy-ethane / 80 °C

With pyrrolidine; bis(benzonitrile)palladium(II) dichloride; hydrogen; tris-(o-tolyl)phosphine; zinc(II) chloride; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00046a001

Reference yield:

4-oxochroman-7-yl trifluoromethanesulfonate (151884-08-1) → Ethyl 1-(3-(4-phenyl-phenylmethyl)-4-chromanon-7-yl)cyclopentane-carboxylate (179107-64-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyrrolidine / methanol / Ambient temperature

2: H₂ / 10percent Pd/C / ethyl acetate / 2068.6 Torr

3: 87 percent / Pd(PhCN)2Cl₂, ZnCl₂, P(o-tol)3 / dimethylformamide; 1,2-dimethoxy-ethane / 80 °C

With pyrrolidine; bis(benzonitrile)palladium(II) dichloride; hydrogen; tris-(o-tolyl)phosphine; zinc(II) chloride; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00046a001

upstream raw materials:

Trifluoro-methanesulfonic acid 3-biphenyl-4-ylmethyl-4-oxo-chroman-7-yl ester

4-Phenylbenzaldehyde

4-oxochroman-7-yl trifluoromethanesulfonate

Trifluoro-methanesulfonic acid 3-[1-biphenyl-4-yl-meth-(E)-ylidene]-4-oxo-chroman-7-yl ester

Downstream raw materials:

1-{(3S,4R)-3-Biphenyl-4-ylmethyl-4-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyloxy]-chroman-7-yl}-cyclopentanecarboxylic acid ethyl ester