N-(2-(tert-butyldimethylsilyloxy)ethyl)-2-phenyl-1-propyl-1H-indol-5-amine

Base Information

Chemical Name:N-(2-(tert-butyldimethylsilyloxy)ethyl)-2-phenyl-1-propyl-1H-indol-5-amine
CAS No.:1415345-96-8
Molecular Formula:C₂₅H₃₆N₂OSi
Molecular Weight:408.659
Hs Code.:

Synonyms:N-(2-(tert-butyldimethylsilyloxy)ethyl)-2-phenyl-1-propyl-1H-indol-5-amine

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Chemical Property of N-(2-(tert-butyldimethylsilyloxy)ethyl)-2-phenyl-1-propyl-1H-indol-5-amine

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Technology Process of N-(2-(tert-butyldimethylsilyloxy)ethyl)-2-phenyl-1-propyl-1H-indol-5-amine

There total 6 articles about N-(2-(tert-butyldimethylsilyloxy)ethyl)-2-phenyl-1-propyl-1H-indol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1415345-95-7
2-phenyl-1-propyl-1H-indol-5-yl trifluoromethanesulfonate

: 101711-55-1
2‐((tert‐butyldimethylsilyl)oxy)ethan‐1‐amine

: 1415345-96-8
N-(2-(tert-butyldimethylsilyloxy)ethyl)-2-phenyl-1-propyl-1H-indol-5-amine

Guidance literature:: With caesium carbonate; XPhos; palladium diacetate; In toluene; at 111 ℃; for 4h; Inert atmosphere;

Reference yield:

: 98-80-6
phenylboronic acid

: 1415345-96-8
N-(2-(tert-butyldimethylsilyloxy)ethyl)-2-phenyl-1-propyl-1H-indol-5-amine

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate / acetic acid / 2 h / 25 °C

2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 25 °C

3: boron tribromide / dichloromethane / 1 h / 0 °C

4: pyridine / dichloromethane / 1 h / 0 °C / Cooling with ice

5: caesium carbonate; XPhos / palladium diacetate / toluene / 4 h / 111 °C / Inert atmosphere

With pyridine; boron tribromide; caesium carbonate; XPhos; palladium diacetate; In dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; 5: buchwald reaction;

Reference yield:

: 1006-94-6
5-methoxylindole

: 1415345-96-8
N-(2-(tert-butyldimethylsilyloxy)ethyl)-2-phenyl-1-propyl-1H-indol-5-amine

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate / acetic acid / 2 h / 25 °C

2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 25 °C

3: boron tribromide / dichloromethane / 1 h / 0 °C

4: pyridine / dichloromethane / 1 h / 0 °C / Cooling with ice

5: caesium carbonate; XPhos / palladium diacetate / toluene / 4 h / 111 °C / Inert atmosphere

With pyridine; boron tribromide; caesium carbonate; XPhos; palladium diacetate; In dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; 5: buchwald reaction;