methyl 2-[(4-chlorobenzyl)amino]-3-methyl-4-oxo-3,4-dihydroquinazoline-7-carboxylate

Base Information

Chemical Name:methyl 2-[(4-chlorobenzyl)amino]-3-methyl-4-oxo-3,4-dihydroquinazoline-7-carboxylate
CAS No.:1372890-05-5
Molecular Formula:C₁₈H₁₆ClN₃O₃
Molecular Weight:357.796
Hs Code.:

Synonyms:methyl 2-[(4-chlorobenzyl)amino]-3-methyl-4-oxo-3,4-dihydroquinazoline-7-carboxylate

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Chemical Property of methyl 2-[(4-chlorobenzyl)amino]-3-methyl-4-oxo-3,4-dihydroquinazoline-7-carboxylate

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Technology Process of methyl 2-[(4-chlorobenzyl)amino]-3-methyl-4-oxo-3,4-dihydroquinazoline-7-carboxylate

There total 4 articles about methyl 2-[(4-chlorobenzyl)amino]-3-methyl-4-oxo-3,4-dihydroquinazoline-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1372890-04-4
methyl 2-chloro-3-methyl-4-oxo-3,4-dihydroquinazoline-7-carboxylate

: 104-86-9
4-chlorobenzylamine

: 1372890-05-5
methyl 2-[(4-chlorobenzyl)amino]-3-methyl-4-oxo-3,4-dihydroquinazoline-7-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 100 ℃; for 1h;

Reference yield:

: 18643-86-2
dimethyl 2-bromoterephthalate

: 1372890-05-5
methyl 2-[(4-chlorobenzyl)amino]-3-methyl-4-oxo-3,4-dihydroquinazoline-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 100 °C

2: phosphorus pentachloride; N,N-diethylaniline; trichlorophosphate / 24 h / 120 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 1 h / 100 °C

With phosphorus pentachloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N,N-diethylaniline; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; isopropyl alcohol;

Reference yield:

: 586-35-6
2-bromo-1,4-benzenedicarboxylic acid

: 1372890-05-5
methyl 2-[(4-chlorobenzyl)amino]-3-methyl-4-oxo-3,4-dihydroquinazoline-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 0 - 20 °C

2: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 100 °C

3: phosphorus pentachloride; N,N-diethylaniline; trichlorophosphate / 24 h / 120 °C

4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 1 h / 100 °C

With thionyl chloride; phosphorus pentachloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N,N-diethylaniline; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; isopropyl alcohol;