N-[4-chloro-3-(trifluoromethyl)benzyl]-2-(2-(dimethylamino)ethoxy)-6-ethoxybenzamide

Base Information

Chemical Name:N-[4-chloro-3-(trifluoromethyl)benzyl]-2-(2-(dimethylamino)ethoxy)-6-ethoxybenzamide
CAS No.:1383934-17-5
Molecular Formula:C₂₁H₂₄ClF₃N₂O₃
Molecular Weight:444.881
Hs Code.:

Synonyms:N-[4-chloro-3-(trifluoromethyl)benzyl]-2-(2-(dimethylamino)ethoxy)-6-ethoxybenzamide

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Chemical Property of N-[4-chloro-3-(trifluoromethyl)benzyl]-2-(2-(dimethylamino)ethoxy)-6-ethoxybenzamide

Chemical Property:

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Technology Process of N-[4-chloro-3-(trifluoromethyl)benzyl]-2-(2-(dimethylamino)ethoxy)-6-ethoxybenzamide

There total 3 articles about N-[4-chloro-3-(trifluoromethyl)benzyl]-2-(2-(dimethylamino)ethoxy)-6-ethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383934-16-4
N-[4-chloro-3-(trifluoromethyl)benzyl]-2-ethoxy-6-hydroxybenzamide

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 1383934-17-5
N-[4-chloro-3-(trifluoromethyl)benzyl]-2-(2-(dimethylamino)ethoxy)-6-ethoxybenzamide

Guidance literature:: N-[4-chloro-3-(trifluoromethyl)benzyl]-2-ethoxy-6-hydroxybenzamide; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 0.5h;

(2-chloroethyl)dimethylamine hydrochloride; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

Reference yield:

: 480439-13-2
2-ethoxy-6-hydroxybenzoic acid

: 1383934-17-5
N-[4-chloro-3-(trifluoromethyl)benzyl]-2-(2-(dimethylamino)ethoxy)-6-ethoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C

2.2: 24 h / 80 °C

With potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 154364-61-1
ethyl 6-ethoxy-2-hydroxybenzoate

: 1383934-17-5
N-[4-chloro-3-(trifluoromethyl)benzyl]-2-(2-(dimethylamino)ethoxy)-6-ethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol / 6 h / Reflux

2.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C

3.2: 24 h / 80 °C

With potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;