(4-(tert-butoxycarbonylamino-methyl)-2-{1-[1-(2-methoxy-ethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid

Base Information

Chemical Name:(4-(tert-butoxycarbonylamino-methyl)-2-{1-[1-(2-methoxy-ethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid
CAS No.:1313042-40-8
Molecular Formula:C₃₂H₃₈F₃N₃O₈
Molecular Weight:649.664
Hs Code.:

Synonyms:(4-(tert-butoxycarbonylamino-methyl)-2-{1-[1-(2-methoxy-ethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid

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Chemical Property of (4-(tert-butoxycarbonylamino-methyl)-2-{1-[1-(2-methoxy-ethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid

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Technology Process of (4-(tert-butoxycarbonylamino-methyl)-2-{1-[1-(2-methoxy-ethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid

There total 15 articles about (4-(tert-butoxycarbonylamino-methyl)-2-{1-[1-(2-methoxy-ethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1313042-31-7
(4-(tert-butoxycarbonylamino-methyl)-2-{1-[1-(2-methoxy-ethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]-piperidin-4-yI}-phenoxy)-acetic acid methyl ester

: 1313042-40-8
(4-(tert-butoxycarbonylamino-methyl)-2-{1-[1-(2-methoxy-ethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid

Guidance literature:: With hydrogenchloride; methanol; at 20 ℃; for 0.5h;

Reference yield:

: 696-60-6
4-aminomethylphenol

: 1313042-40-8
(4-(tert-butoxycarbonylamino-methyl)-2-{1-[1-(2-methoxy-ethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: bromine; hydrogen bromide / acetic acid / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: caesium carbonate / tetrahydrofuran / 20 °C

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 80 °C

5: hydrogen; acetic acid / platinum(IV) oxide / methanol / 3 h / 20 °C / 2585.81 - 3102.97 Torr

6: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

7: hydrogenchloride; methanol / 0.5 h / 20 °C

With hydrogenchloride; methanol; hydrogen bromide; hydrogen; bromine; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid;

Reference yield:

: 1535-75-7
2-trifluoromethoxy aniline

: 1313042-40-8
(4-(tert-butoxycarbonylamino-methyl)-2-{1-[1-(2-methoxy-ethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / -5 - 20 °C

1.2: 3.5 h / 20 °C / Reflux

2.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 1 h / -78 °C

2.2: 0.67 h / -78 °C

3.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 20 °C

3.2: 1.5 h / 20 °C

4.1: potassium hydroxide; tert-butyl alcohol / 2 h / 80 °C

5.1: potassium hydroxide / dimethyl sulfoxide / 0.75 h / 20 °C / Inert atmosphere

5.2: 20 °C

6.1: N,N-dimethyl-formamide / 3.5 h / 0 °C

7.1: sodium hydroxide / 48 h / 90 °C

7.2: pH 4

8.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

9.1: hydrogenchloride; methanol / 0.5 h / 20 °C

With hydrogenchloride; methanol; sec.-butyllithium; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; tert-butyl alcohol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; cyclohexane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;