2-nitrophenyl 3-ethoxy-2-methylacryloylcarbamate

Base Information

• Chemical Name: 2-nitrophenyl 3-ethoxy-2-methylacryloylcarbamate
• CAS No.: 1193318-58-9
• Molecular Formula: C₁₃H₁₄N₂O₆
• Molecular Weight: 294.264
• Mol file: 1193318-58-9.mol

Synonyms:2-nitrophenyl 3-ethoxy-2-methylacryloylcarbamate

Chemical Property of 2-nitrophenyl 3-ethoxy-2-methylacryloylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-nitrophenyl 3-ethoxy-2-methylacryloylcarbamate

There total 1 articles about 2-nitrophenyl 3-ethoxy-2-methylacryloylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

ethyl 1-propenyl ether (928-55-2) + chlorocarbonyl isocyanate (27738-96-1) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → 2-nitrophenyl 3-ethoxy-2-methylacryloylcarbamate (1193318-58-9)

Guidance literature:

ethyl 1-propenyl ether; chlorocarbonyl isocyanate; With triethylamine; In 1,4-dioxane; at 10 ℃; for 0.333333h; Inert atmosphere;

2-hydroxynitrobenzene; In 1,4-dioxane; at 10 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tet.2009.08.019

Reference yield: 99.0%

2-nitrophenyl 3-ethoxy-2-methylacryloylcarbamate (1193318-58-9) + (3S,4R)-4-amino-1-N-Boc-3-dimethoxytrityloxypyrrolidine (1193318-61-4) → 1-((3S,4R)-1-N-Boc-3-dimethoxytrityloxy-4-pyrrolidinyl)-3-(3-ethoxy-2-methylacryloyl)urea (1193318-76-1)

Guidance literature:

In 1,4-dioxane; at 20 ℃; for 0.333333h;

DOI:10.1016/j.tet.2009.08.019

Reference yield: 96.0%

2-nitrophenyl 3-ethoxy-2-methylacryloylcarbamate (1193318-58-9) + trans-2-aminocyclohexanol hydrochloride (5456-63-3) → 1-(3-ethoxy-2-methylacryloyl)-3-(trans-2-hydroxycyclohexyl)-urea

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at -20 ℃; for 0.333333h;

DOI:10.1016/j.tet.2009.08.019

upstream raw materials:

ethyl 1-propenyl ether

chlorocarbonyl isocyanate

2-hydroxynitrobenzene

Downstream raw materials:

1-((3S,4R)-1-N-Boc-3-dimethoxytrityloxy-4-pyrrolidinyl)-3-(3-ethoxy-2-methylacryloyl)urea

1-cyclohexyl-3-(3-ethoxy-2-methylacryloyl)urea

1-(3-ethoxy-2-methylacryloyl)-3-phenylurea

2-nitrophenyl 3-ethoxyacryloylcarbamate