3-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}-N-ethylbenzamide

Base Information

Chemical Name:3-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}-N-ethylbenzamide
CAS No.:1309681-02-4
Molecular Formula:C₂₂H₁₈N₆O
Molecular Weight:382.425
Hs Code.:

Synonyms:3-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}-N-ethylbenzamide

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Chemical Property of 3-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}-N-ethylbenzamide

Chemical Property:

Purity/Quality:

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Technology Process of 3-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}-N-ethylbenzamide

There total 6 articles about 3-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}-N-ethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309593-80-3
ethyl 3-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}benzoate

: 75-04-7,85404-22-4
ethylamine

: 1309681-02-4
3-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}-N-ethylbenzamide

Guidance literature:: With potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 1010120-60-1
ethyl [(5-bromopyridin-2-yl)carbamothioyl]carbamate

: 1309681-02-4
3-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}-N-ethylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol; methanol / 2 h / 60 °C

2: potassium carbonate / triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / propan-1-ol / 15 h / Reflux

3: thionyl chloride / 144 h / 0 °C / Reflux

4: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 3 h / Inert atmosphere; Reflux

5: potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 24 h / 20 °C

With thionyl chloride; hydroxylamine hydrochloride; potassium carbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; In methanol; propan-1-ol; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1309681-02-4
3-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}-N-ethylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1,4-dioxane / 2 h / 20 °C

2: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol; methanol / 2 h / 60 °C

3: potassium carbonate / triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / propan-1-ol / 15 h / Reflux

4: thionyl chloride / 144 h / 0 °C / Reflux

5: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 3 h / Inert atmosphere; Reflux

6: potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 24 h / 20 °C

With thionyl chloride; hydroxylamine hydrochloride; potassium carbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; In 1,4-dioxane; methanol; propan-1-ol; ethanol; N,N-dimethyl-formamide; toluene;