[(S)-6-(3-Benzyloxy-propyl)-6-methyl-cyclohex-1-enylethynyl]-trimethyl-silane

Base Information

Chemical Name:[(S)-6-(3-Benzyloxy-propyl)-6-methyl-cyclohex-1-enylethynyl]-trimethyl-silane
CAS No.:352695-09-1
Molecular Formula:C₂₂H₃₂OSi
Molecular Weight:340.581
Hs Code.:

Synonyms:[(S)-6-(3-Benzyloxy-propyl)-6-methyl-cyclohex-1-enylethynyl]-trimethyl-silane

Suppliers and Price of [(S)-6-(3-Benzyloxy-propyl)-6-methyl-cyclohex-1-enylethynyl]-trimethyl-silane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(S)-6-(3-Benzyloxy-propyl)-6-methyl-cyclohex-1-enylethynyl]-trimethyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(S)-6-(3-Benzyloxy-propyl)-6-methyl-cyclohex-1-enylethynyl]-trimethyl-silane

There total 7 articles about [(S)-6-(3-Benzyloxy-propyl)-6-methyl-cyclohex-1-enylethynyl]-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 352695-19-3
Trifluoro-methanesulfonic acid (S)-6-(3-benzyloxy-propyl)-6-methyl-cyclohex-1-enyl ester

: 1066-54-2
trimethylsilylacetylene

: 352695-09-1
[(S)-6-(3-Benzyloxy-propyl)-6-methyl-cyclohex-1-enylethynyl]-trimethyl-silane

Guidance literature:: With copper(l) iodide; N-butylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 22 ℃; for 3h;
DOI:10.1021/ol016073k

Reference yield:

: 53068-89-6,94089-47-1,150927-14-3,112898-44-9
(S)-3-(1-methyl-2-oxocyclohexyl)-propionic acid methyl ester

: 352695-09-1
[(S)-6-(3-Benzyloxy-propyl)-6-methyl-cyclohex-1-enylethynyl]-trimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1.1: LiAlH₄ / tetrahydrofuran / 0.75 h / 22 °C

1.2: aq.NaH / H₂O; tetrahydrofuran / 1 h / 0 °C

2.1: 82 percent / NaH / tetrahydrofuran / 5 h / 22 °C

3.1: 92 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / 0.75 h / -78 °C

4.1: LDA / tetrahydrofuran; various solvent(s) / 2 h / -78 °C

4.2: 84 percent / tetrahydrofuran; various solvent(s) / 0 - 22 °C

5.1: 96 percent / CuI; BuNH₂ / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 3 h / 22 °C

With copper(l) iodide; lithium aluminium tetrahydride; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; N-butylamine; triethylamine; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; 3.1: Swern oxidation / 5.1: Sonogashira coupling reaction;
DOI:10.1021/ol016073k

Reference yield:

: 100-39-0
benzyl bromide

: 352695-09-1
[(S)-6-(3-Benzyloxy-propyl)-6-methyl-cyclohex-1-enylethynyl]-trimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / NaH / tetrahydrofuran / 5 h / 22 °C

2.1: 92 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / 0.75 h / -78 °C

3.1: LDA / tetrahydrofuran; various solvent(s) / 2 h / -78 °C

3.2: 84 percent / tetrahydrofuran; various solvent(s) / 0 - 22 °C

4.1: 96 percent / CuI; BuNH₂ / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 3 h / 22 °C

With copper(l) iodide; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; N-butylamine; triethylamine; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; 2.1: Swern oxidation / 4.1: Sonogashira coupling reaction;
DOI:10.1021/ol016073k