Trifluoro-methanesulfonic acid (S)-6-(3-benzyloxy-propyl)-6-methyl-cyclohex-1-enyl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid (S)-6-(3-benzyloxy-propyl)-6-methyl-cyclohex-1-enyl ester
CAS No.:352695-19-3
Molecular Formula:C₁₈H₂₃F₃O₄S
Molecular Weight:392.439
Hs Code.:

Synonyms:Trifluoro-methanesulfonic acid (S)-6-(3-benzyloxy-propyl)-6-methyl-cyclohex-1-enyl ester

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Chemical Property of Trifluoro-methanesulfonic acid (S)-6-(3-benzyloxy-propyl)-6-methyl-cyclohex-1-enyl ester

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Technology Process of Trifluoro-methanesulfonic acid (S)-6-(3-benzyloxy-propyl)-6-methyl-cyclohex-1-enyl ester

There total 6 articles about Trifluoro-methanesulfonic acid (S)-6-(3-benzyloxy-propyl)-6-methyl-cyclohex-1-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 211235-31-3
(-)-2-(3-benzyloxypropyl)-2-methylcyclohexanone

: 352695-19-3
Trifluoro-methanesulfonic acid (S)-6-(3-benzyloxy-propyl)-6-methyl-cyclohex-1-enyl ester

Guidance literature:: (-)-2-(3-benzyloxypropyl)-2-methylcyclohexanone; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h;

N,N-phenylbistrifluoromethane-sulfonimide; In tetrahydrofuran; at 0 - 22 ℃; Further stages.;
DOI:10.1021/ol016073k

Reference yield:

: 100-39-0
benzyl bromide

: 352695-19-3
Trifluoro-methanesulfonic acid (S)-6-(3-benzyloxy-propyl)-6-methyl-cyclohex-1-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 82 percent / NaH / tetrahydrofuran / 5 h / 22 °C

2.1: 92 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / 0.75 h / -78 °C

3.1: LDA / tetrahydrofuran; various solvent(s) / 2 h / -78 °C

3.2: 84 percent / tetrahydrofuran; various solvent(s) / 0 - 22 °C

With oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 2.1: Swern oxidation;
DOI:10.1021/ol016073k

Reference yield:

: 53068-89-6,94089-47-1,150927-14-3,112898-44-9
(S)-3-(1-methyl-2-oxocyclohexyl)-propionic acid methyl ester

: 352695-19-3
Trifluoro-methanesulfonic acid (S)-6-(3-benzyloxy-propyl)-6-methyl-cyclohex-1-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiAlH₄ / tetrahydrofuran / 0.75 h / 22 °C

1.2: aq.NaH / H₂O; tetrahydrofuran / 1 h / 0 °C

2.1: 82 percent / NaH / tetrahydrofuran / 5 h / 22 °C

3.1: 92 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / 0.75 h / -78 °C

4.1: LDA / tetrahydrofuran; various solvent(s) / 2 h / -78 °C

4.2: 84 percent / tetrahydrofuran; various solvent(s) / 0 - 22 °C

With lithium aluminium tetrahydride; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 3.1: Swern oxidation;
DOI:10.1021/ol016073k