5-fluoro-1-{[2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carbonyl]-amino}-1H-indole-3-carboxylic acid amide

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Chemical Name:5-fluoro-1-{[2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carbonyl]-amino}-1H-indole-3-carboxylic acid amide
CAS No.:1068970-87-5
Molecular Formula:C₂₁H₁₅F₂N₅O₂
Molecular Weight:407.379
Hs Code.:

Synonyms:5-fluoro-1-{[2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carbonyl]-amino}-1H-indole-3-carboxylic acid amide

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Chemical Property of 5-fluoro-1-{[2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carbonyl]-amino}-1H-indole-3-carboxylic acid amide

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Technology Process of 5-fluoro-1-{[2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carbonyl]-amino}-1H-indole-3-carboxylic acid amide

There total 6 articles about 5-fluoro-1-{[2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carbonyl]-amino}-1H-indole-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1189-71-5
isocyanate de chlorosulfonyle

: 1068970-28-4
2-(3-fluorophenyl)-4-methylpyrimidine-5-carboxylic acid (5-fluoroindol-1-yl)amide

: 1068970-87-5
5-fluoro-1-{[2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carbonyl]-amino}-1H-indole-3-carboxylic acid amide

Guidance literature:: isocyanate de chlorosulfonyle; 2-(3-fluorophenyl)-4-methylpyrimidine-5-carboxylic acid (5-fluoroindol-1-yl)amide; In 2-methyltetrahydrofuran; at 0 - 20 ℃; for 2h;

With sodium hydroxide; water; In 2-methyltetrahydrofuran; at 0 ℃;

Reference yield:

: 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid ethyl ester

: 1068970-87-5
5-fluoro-1-{[2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carbonyl]-amino}-1H-indole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol; sodium hydroxide; water / tetrahydrofuran / 0.75 h / Heating / reflux

1.2: pH 2 - 3

2.1: N,N-diethyl-N-isopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 8 h / 20 - 80 °C

3.1: 2-methyltetrahydrofuran / 2 h / 0 - 20 °C

3.2: 0 °C

With methanol; sodium hydroxide; N,N-diethyl-N-isopropylamine; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; 2-methyltetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 75207-72-6
3-fluorobenzenecarboximidamide hydrochloride

: 1068970-87-5
5-fluoro-1-{[2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carbonyl]-amino}-1H-indole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; sodium / 0.5 h / 20 °C

1.2: 1 h / Heating / reflux

2.1: methanol; sodium hydroxide; water / tetrahydrofuran / 0.75 h / Heating / reflux

2.2: pH 2 - 3

3.1: N,N-diethyl-N-isopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 8 h / 20 - 80 °C

4.1: 2-methyltetrahydrofuran / 2 h / 0 - 20 °C

4.2: 0 °C

With methanol; sodium hydroxide; ethanol; N,N-diethyl-N-isopropylamine; water; sodium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; 2-methyltetrahydrofuran; N,N-dimethyl-formamide;