methyl 6-[2-((Z)-3-diethylarninoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxy-3-[2-(1-hydroxyethyl)-furan-3-yl]-benzoate

Base Information

Chemical Name:methyl 6-[2-((Z)-3-diethylarninoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxy-3-[2-(1-hydroxyethyl)-furan-3-yl]-benzoate
CAS No.:1356112-98-5
Molecular Formula:C₂₈H₃₂FNO₇S
Molecular Weight:545.629
Hs Code.:

Synonyms:methyl 6-[2-((Z)-3-diethylarninoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxy-3-[2-(1-hydroxyethyl)-furan-3-yl]-benzoate

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Chemical Property of methyl 6-[2-((Z)-3-diethylarninoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxy-3-[2-(1-hydroxyethyl)-furan-3-yl]-benzoate

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Technology Process of methyl 6-[2-((Z)-3-diethylarninoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxy-3-[2-(1-hydroxyethyl)-furan-3-yl]-benzoate

There total 9 articles about methyl 6-[2-((Z)-3-diethylarninoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxy-3-[2-(1-hydroxyethyl)-furan-3-yl]-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356113-03-5
methyl 3-(2-acetylfuran-3-yl)-6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxybenzoate

: 1356112-98-5
methyl 6-[2-((Z)-3-diethylarninoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxy-3-[2-(1-hydroxyethyl)-furan-3-yl]-benzoate

Guidance literature:: With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 10 - 20 ℃; for 0.166667h;

Reference yield:

: 681247-87-0,681247-88-1
N,N-diethyl-N-((Z)-1-tributylstannanylprop-1-en-3-yl)-amine

: 1356112-98-5
methyl 6-[2-((Z)-3-diethylarninoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxy-3-[2-(1-hydroxyethyl)-furan-3-yl]-benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; Reflux

2: aluminum (III) chloride; N,N-dimethyl-aniline / dichloromethane / 2 h / 0 - 20 °C

3: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

4: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.17 h / 10 - 20 °C

With methanol; aluminum (III) chloride; sodium tetrahydroborate; caesium carbonate; N,N-dimethyl-aniline; cesium fluoride; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1286179-94-9
methyl 3-bromo-6-bromomethyl-2-methoxybenzoate

: 1356112-98-5
methyl 6-[2-((Z)-3-diethylarninoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxy-3-[2-(1-hydroxyethyl)-furan-3-yl]-benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrahydrofuran / 1 h / Reflux

1.2: 2 h / 20 - 80 °C

2.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; Reflux

3.1: aluminum (III) chloride; N,N-dimethyl-aniline / dichloromethane / 2 h / 0 - 20 °C

4.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

5.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.17 h / 10 - 20 °C

With methanol; aluminum (III) chloride; sodium tetrahydroborate; potassium carbonate; caesium carbonate; N,N-dimethyl-aniline; cesium fluoride; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;