α,α-bisphenyl-5-pyrimidinemethanol

Base Information

• Chemical Name: α,α-bisphenyl-5-pyrimidinemethanol
• CAS No.: 26766-19-8
• Molecular Formula: C₁₇H₁₄N₂O
• Molecular Weight: 262.311
• Mol file: 26766-19-8.mol

Synonyms:α,α-bisphenyl-5-pyrimidinemethanol

Chemical Property of α,α-bisphenyl-5-pyrimidinemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α,α-bisphenyl-5-pyrimidinemethanol

There total 5 articles about α,α-bisphenyl-5-pyrimidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

5-bromopyrimidine (4595-59-9) + benzophenone (119-61-9) → α,α-bisphenyl-5-pyrimidinemethanol (26766-19-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -80 - 20 ℃;

DOI:10.1271/bbb.65.817

Reference yield: 48.0%

PYRIMIDINE (289-95-2,25247-63-6) + benzophenone (119-61-9) → α,α-bisphenyl-5-pyrimidinemethanol (26766-19-8)

Guidance literature:

With t-Bu-P₄ base; zinc(II) iodide; In toluene; at -78 - 20 ℃;

DOI:10.1021/ja0342300

Reference yield:

benzophenone (119-61-9) → α,α-bisphenyl-5-pyrimidinemethanol (26766-19-8)

Guidance literature:

5-bromopyrimidine; With n-butyllithium; In tetrahydrofuran; hexane; at -100 ℃; for 1h;

benzophenone; In tetrahydrofuran; hexane; at -100 - 20 ℃; for 1.5h;

upstream raw materials:

5-bromopyrimidine

benzophenone

PYRIMIDINE

Downstream raw materials:

C₁₇H₁₃ClN₂

5'-[diphenyl-(5-pyrimidyl)methyl]amino-2',5'-dideoxyuridine

5'-[diphenyl(5-pyrimidyl)methyl]-2'-deoxyuridine

Refernces

• 1、 Imahori, Tatsushi,Kondo, Yoshinori. "A new strategy for deprotonative functionalization of aromatics: Transformations with excellent chemoselectivity and unique regioselectivities using t-Bu-P4 base". . p. 8082 - 8083. Retrieved 2007/10/03.
• 2、 Slama, James T.,Hancock, Julie L.,Rho, Taikyun,Sambucetti, Lidia,Bachmann, Kenneth A.. "Influence of some novel N-substituted azoles and pyridines on rat hepatic CYP3A activity". . p. 1881 - 1892. Retrieved 2008/04/18.