D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)<1-2H>propanal

Base Information

Chemical Name:D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)<1-2H>propanal
CAS No.:96363-22-3
Molecular Formula:C₁₅H₂₁NO₄
Molecular Weight:280.328
Hs Code.:

Synonyms:D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)<1-2H>propanal

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Chemical Property of D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)<1-2H>propanal

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Technology Process of D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)<1-2H>propanal

There total 3 articles about D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)<1-2H>propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 96363-21-2
methyl D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)propanoate

: 96363-22-3
D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)<1-2H>propanal

Guidance literature:: With diisobutylaluminium deuteride; rochelle salt; In methanol; diethyl ether; hexane; toluene; at -78 ℃; for 0.1h;
DOI:10.1016/S0040-4020(01)91486-3

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 96363-22-3
D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)<1-2H>propanal

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / ammonium acetate / ethanol; H₂O / 13 h / Heating

2: 88 percent / 1 N NaOH / dioxane; H₂O / 1.) 0 deg C, 10 min, 2.) RT, 3 h

3: 87 percent / 4-(dimethylamino)pyridine (DMAP), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 12 h / Ambient temperature

4: 75 percent / DIBAL-2H / toluene; hexane; diethyl ether / 0.1 h / -78 °C

With ammonium acetate; dmap; sodium hydroxide; diisobutylaluminium deuteride; dicyclohexyl-carbodiimide; In 1,4-dioxane; diethyl ether; ethanol; hexane; dichloromethane; water; toluene;
DOI:10.1021/jo00213a012

Reference yield:

: 96363-20-1,500788-87-4
D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)propanoic acid

: 96363-22-3
D,L-3-<<(1,1-dimethylethoxy)carbonyl>amino>-3-(4-methoxyphenyl)<1-2H>propanal

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / 4-(dimethylamino)pyridine (DMAP), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 12 h / Ambient temperature

2: 75 percent / DIBAL-2H / toluene; hexane; diethyl ether / 0.1 h / -78 °C

With dmap; diisobutylaluminium deuteride; dicyclohexyl-carbodiimide; In diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1021/jo00213a012