3-<2-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>quinuclidine

Base Information

Chemical Name:3-<2-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>quinuclidine
CAS No.:142843-11-6
Molecular Formula:C₂₄H₄₃N₃O₄S
Molecular Weight:469.689
Hs Code.:

Synonyms:3-<2-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>quinuclidine

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Chemical Property of 3-<2-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>quinuclidine

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Technology Process of 3-<2-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>quinuclidine

There total 2 articles about 3-<2-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>quinuclidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 76883-48-2,120570-05-0,123536-15-2,6238-14-8,781591-76-2
quinuclidin-3-amine

: 142843-07-0
ethyl 2-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetate

: 142843-11-6
3-<2-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>quinuclidine

Guidance literature:: In ethanol; at 90 ℃; for 3h;
DOI:10.1021/jm00093a009

Reference yield:

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 142843-11-6
3-<2-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>quinuclidine

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / triethylamine / ethanol

2: 75 percent / ethanol / 3 h / 90 °C

With triethylamine; In ethanol;
DOI:10.1021/jm00093a009

Reference yield:

: 142843-11-6
3-<2-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetamido>quinuclidine

: 143396-51-4
{(S)-1-[(S)-1-{(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-[(1-oxy-1-aza-bicyclo[2.2.2]oct-3-ylcarbamoyl)-methanesulfonyl]-propylcarbamoyl}-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: ethanolic HCl / 1 h / Ambient temperature

2: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), triethylamine / CH₂Cl₂ / 17 h / Ambient temperature

3: 40 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 24 percent / NH₃ (gas) / methanol / 3 h / Ambient temperature

With hydrogenchloride; ammonia; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;
DOI:10.1021/jm00093a009