N-(4-(3-bromophenylamino)quinazolin-6-yl)-3-(dimethylamino)-N-methylpropanamide

Base Information

Chemical Name:N-(4-(3-bromophenylamino)quinazolin-6-yl)-3-(dimethylamino)-N-methylpropanamide
CAS No.:1360430-58-5
Molecular Formula:C₂₀H₂₂BrN₅O
Molecular Weight:428.332
Hs Code.:

Synonyms:N-(4-(3-bromophenylamino)quinazolin-6-yl)-3-(dimethylamino)-N-methylpropanamide

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Chemical Property of N-(4-(3-bromophenylamino)quinazolin-6-yl)-3-(dimethylamino)-N-methylpropanamide

Chemical Property:

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Technology Process of N-(4-(3-bromophenylamino)quinazolin-6-yl)-3-(dimethylamino)-N-methylpropanamide

There total 7 articles about N-(4-(3-bromophenylamino)quinazolin-6-yl)-3-(dimethylamino)-N-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1360430-74-5
N-(4-(3-bromoanilino)quinazolin-6-yl)-3-chloro-N-methylpropanamide

: 124-40-3
dimethyl amine

: 1360430-58-5
N-(4-(3-bromophenylamino)quinazolin-6-yl)-3-(dimethylamino)-N-methylpropanamide

Guidance literature:: N-(4-(3-bromoanilino)quinazolin-6-yl)-3-chloro-N-methylpropanamide; dimethyl amine; With potassium iodide; In ethanol; Reflux;

With potassium hydroxide; In ethanol; at 0 ℃;
DOI:10.1021/jm201507x

Reference yield:

: 17420-30-3
5-nitroanthranilonitrile

: 1360430-58-5
N-(4-(3-bromophenylamino)quinazolin-6-yl)-3-(dimethylamino)-N-methylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / Reflux

2.1: thionyl chloride / 1,4-dioxane / Reflux

2.2: 60 °C

3.1: iron; acetic acid / ethanol; water / Reflux

4.1: pyridine / 5 h / 0 - 20 °C

5.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / Cooling with ice; Reflux

6.1: 5 h / 50 °C

7.1: potassium iodide / ethanol / Reflux

7.2: 0 °C

With pyridine; thionyl chloride; sulfuric acid; iron; acetic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; potassium iodide; In tetrahydrofuran; 1,4-dioxane; ethanol; water;
DOI:10.1021/jm201507x

Reference yield:

: ethyl 4-(3-bromoanilino)quinazolin-6-ylcarbamate

: 1360430-58-5
N-(4-(3-bromophenylamino)quinazolin-6-yl)-3-(dimethylamino)-N-methylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / Cooling with ice; Reflux

2.1: 5 h / 50 °C

3.1: potassium iodide / ethanol / Reflux

3.2: 0 °C

With sodium bis(2-methoxyethoxy)aluminium dihydride; potassium iodide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm201507x