(R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:82775-54-0
Molecular Formula:C₃₄H₃₅NO₆
Molecular Weight:553.655
Hs Code.:

Synonyms:(R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of (R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of (R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

There total 2 articles about (R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 100-44-7
benzyl chloride

: 82775-53-9
(R)-N-formyl-5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

: 82775-54-0
(R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With potassium carbonate; sodium iodide; In dimethyl sulfoxide; 1.) room temp. 19.5 h., 2.) 40 deg C, 1 h.;
DOI:10.1248/cpb.31.70

Reference yield:

: 71605-46-4,67950-89-4
(R)-1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-5,7-diol

: 82775-54-0
(R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Ac₂O, 2.) 30percent aq. K₂CO₃ / 1.) THF, room temp., 2 h., 2.) THF, water, room temp.

2: 86 percent / NaI, K₂CO₃ / dimethylsulfoxide / 1.) room temp. 19.5 h., 2.) 40 deg C, 1 h.

With acetic anhydride; potassium carbonate; sodium iodide; In dimethyl sulfoxide;
DOI:10.1248/cpb.31.70

Reference yield:

: 82775-54-0
(R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

: 63571-30-2,67950-89-4
(+/-)-TA-073

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 10percent aq. NaOH, 2.) 10percent ethanolic HCl / 1.) 17.5 h., reflux, ethanol, 2.) water

2: 100 percent / NaNO₂ / ethanol; acetic acid / 1.5 h / Ambient temperature

3: 1.) dimsyl anion, 2.) 10percent aq. HCl / 1.) DMSO, 20-22 deg C, 10 min., 2.) DMSO, water

4: 1.) NaBH₄, 2.) 10percent ethanolic HCl / 1.) room temp., 2 h., 2.) ethanol

5: hydrogen / 10percent Pd-C / methanol / 17.5 h / 50 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; dimethyl sulfoxide; deprotonated form; hydrogen; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; acetic acid;
DOI:10.1248/cpb.31.70