(R)-N-formyl-5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(R)-N-formyl-5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:82775-53-9
Molecular Formula:C₂₀H₂₃NO₆
Molecular Weight:373.406
Hs Code.:

Synonyms:(R)-N-formyl-5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of (R)-N-formyl-5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-formyl-5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (R)-N-formyl-5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about (R)-N-formyl-5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-18-6
formic acid

: 71605-46-4,67950-89-4
(R)-1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-5,7-diol

: 82775-53-9
(R)-N-formyl-5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With acetic anhydride; potassium carbonate; Yield given. Multistep reaction; 1.) THF, room temp., 2 h., 2.) THF, water, room temp.;
DOI:10.1248/cpb.31.70

Reference yield: 86.0%

: 100-44-7
benzyl chloride

: 82775-53-9
(R)-N-formyl-5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

: 82775-54-0
(R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With potassium carbonate; sodium iodide; In dimethyl sulfoxide; 1.) room temp. 19.5 h., 2.) 40 deg C, 1 h.;
DOI:10.1248/cpb.31.70

Reference yield:

: 82775-53-9
(R)-N-formyl-5,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

: 63571-30-2,67950-89-4
(+/-)-TA-073

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / NaI, K₂CO₃ / dimethylsulfoxide / 1.) room temp. 19.5 h., 2.) 40 deg C, 1 h.

2: 1.) 10percent aq. NaOH, 2.) 10percent ethanolic HCl / 1.) 17.5 h., reflux, ethanol, 2.) water

3: 100 percent / NaNO₂ / ethanol; acetic acid / 1.5 h / Ambient temperature

4: 1.) dimsyl anion, 2.) 10percent aq. HCl / 1.) DMSO, 20-22 deg C, 10 min., 2.) DMSO, water

5: 1.) NaBH₄, 2.) 10percent ethanolic HCl / 1.) room temp., 2 h., 2.) ethanol

6: hydrogen / 10percent Pd-C / methanol / 17.5 h / 50 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; dimethyl sulfoxide; deprotonated form; hydrogen; potassium carbonate; sodium iodide; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; acetic acid; dimethyl sulfoxide;
DOI:10.1248/cpb.31.70