(R)-5,7-dibenzyloxy-N-nitroso-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(R)-5,7-dibenzyloxy-N-nitroso-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:86439-43-2
Molecular Formula:C₃₃H₃₄N₂O₆
Molecular Weight:554.643
Hs Code.:

Synonyms:(R)-5,7-dibenzyloxy-N-nitroso-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5,7-dibenzyloxy-N-nitroso-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of (R)-5,7-dibenzyloxy-N-nitroso-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about (R)-5,7-dibenzyloxy-N-nitroso-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 86495-21-8
(R)-5,7-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 86439-43-2
(R)-5,7-dibenzyloxy-N-nitroso-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium nitrite; In ethanol; acetic acid; for 1.5h; Ambient temperature;
DOI:10.1248/cpb.31.70

Reference yield:

: 82775-54-0
(R)-5,7-dibenzyloxy-N-formyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

: 86439-43-2
(R)-5,7-dibenzyloxy-N-nitroso-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 10percent aq. NaOH, 2.) 10percent ethanolic HCl / 1.) 17.5 h., reflux, ethanol, 2.) water

2: 100 percent / NaNO₂ / ethanol; acetic acid / 1.5 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium nitrite; In ethanol; acetic acid;
DOI:10.1248/cpb.31.70

Reference yield:

: 71605-46-4,67950-89-4
(R)-1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-5,7-diol

: 86439-43-2
(R)-5,7-dibenzyloxy-N-nitroso-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Ac₂O, 2.) 30percent aq. K₂CO₃ / 1.) THF, room temp., 2 h., 2.) THF, water, room temp.

2: 86 percent / NaI, K₂CO₃ / dimethylsulfoxide / 1.) room temp. 19.5 h., 2.) 40 deg C, 1 h.

3: 1.) 10percent aq. NaOH, 2.) 10percent ethanolic HCl / 1.) 17.5 h., reflux, ethanol, 2.) water

4: 100 percent / NaNO₂ / ethanol; acetic acid / 1.5 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; acetic anhydride; potassium carbonate; sodium iodide; sodium nitrite; In ethanol; acetic acid; dimethyl sulfoxide;
DOI:10.1248/cpb.31.70