2-[3,5-Dichloro-4-(morpholine-4-sulfonyl)-phenyl]-2H-[1,2,4]triazine-3,5-dione

Base Information

Chemical Name:2-[3,5-Dichloro-4-(morpholine-4-sulfonyl)-phenyl]-2H-[1,2,4]triazine-3,5-dione
CAS No.:74875-26-6
Molecular Formula:C₁₃H₁₂Cl₂N₄O₅S
Molecular Weight:407.234
Hs Code.:

Synonyms:2-[3,5-Dichloro-4-(morpholine-4-sulfonyl)-phenyl]-2H-[1,2,4]triazine-3,5-dione

Suppliers and Price of 2-[3,5-Dichloro-4-(morpholine-4-sulfonyl)-phenyl]-2H-[1,2,4]triazine-3,5-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[3,5-Dichloro-4-(morpholine-4-sulfonyl)-phenyl]-2H-[1,2,4]triazine-3,5-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-[3,5-Dichloro-4-(morpholine-4-sulfonyl)-phenyl]-2H-[1,2,4]triazine-3,5-dione

There total 6 articles about 2-[3,5-Dichloro-4-(morpholine-4-sulfonyl)-phenyl]-2H-[1,2,4]triazine-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 74875-24-4
2-<3,5-dichloro-4-(morpholinylsulfonyl)phenyl>-3,5(2H,4H)-dioxo-as-triazine-6-carboxylic acid

: 74875-26-6
2-[3,5-Dichloro-4-(morpholine-4-sulfonyl)-phenyl]-2H-[1,2,4]triazine-3,5-dione

Guidance literature:: With mercaptoacetic acid; at 165 ℃; for 2h;
DOI:10.1021/jm00184a005

Reference yield:

: 74875-17-5
2,6-dichloro-4-nitrobenzenesulfonyl chloride

: 74875-26-6
2-[3,5-Dichloro-4-(morpholine-4-sulfonyl)-phenyl]-2H-[1,2,4]triazine-3,5-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 2.64 g / diethyl ether / 3 h / Heating

2: 73 percent / SnCl₂*2H₂O, conc. aq. HCl / 1.25 h / Heating

3: 1.) 6 N aq. HCl, NaNO₂, 2.) pyridine / 1.) from 0 to 5 deg C, 2.) RT, 16 h

4: NaOAc, AcOH / 7 h / Heating

5: aq. HCl / acetic acid / 1.5 h / Heating

6: 68 percent / thioglycolic acid / 2 h / 165 °C

With pyridine; hydrogenchloride; sodium acetate; acetic acid; mercaptoacetic acid; tin(ll) chloride; sodium nitrite; In diethyl ether; acetic acid;
DOI:10.1021/jm00184a005

Reference yield:

: 74875-19-7
3,5-dichloro-4-(morpholinylsulfonyl)aniline

: 74875-26-6
2-[3,5-Dichloro-4-(morpholine-4-sulfonyl)-phenyl]-2H-[1,2,4]triazine-3,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 6 N aq. HCl, NaNO₂, 2.) pyridine / 1.) from 0 to 5 deg C, 2.) RT, 16 h

2: NaOAc, AcOH / 7 h / Heating

3: aq. HCl / acetic acid / 1.5 h / Heating

4: 68 percent / thioglycolic acid / 2 h / 165 °C

With pyridine; hydrogenchloride; sodium acetate; acetic acid; mercaptoacetic acid; sodium nitrite; In acetic acid;
DOI:10.1021/jm00184a005