4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 2-(4-hydroxy-3-iodo-phenyl)-ethyl ester

Base Information

Chemical Name:4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 2-(4-hydroxy-3-iodo-phenyl)-ethyl ester
CAS No.:212260-31-6
Molecular Formula:C₂₄H₂₉IO₆
Molecular Weight:540.395
Hs Code.:

Synonyms:4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 2-(4-hydroxy-3-iodo-phenyl)-ethyl ester

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Chemical Property of 4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 2-(4-hydroxy-3-iodo-phenyl)-ethyl ester

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Technology Process of 4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 2-(4-hydroxy-3-iodo-phenyl)-ethyl ester

There total 4 articles about 4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 2-(4-hydroxy-3-iodo-phenyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2067-33-6
5-bromopentanoic acid

: 212260-31-6
4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 2-(4-hydroxy-3-iodo-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / H₂SO₄ / CH₂Cl₂ / 48 h / Ambient temperature

2: 93 percent / NaH, NaI / dimethylformamide / 20 h / 60 °C

3: 88 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 12 h / Ambient temperature

4: 1.) chlorenamine, 2.) pyridine, DMAP, Et₃N, 3.) hydrazine hydrate / 2.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h, 3.) ethyleneglycol, dioxane, RT, 18 h

With pyridine; dmap; chlorenamine; sulfuric acid; hydrogen; sodium hydride; hydrazine hydrate; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01172-1

Reference yield:

: 88987-42-2
tert-butyl 5-bromovalerate

: 212260-31-6
4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 2-(4-hydroxy-3-iodo-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / NaH, NaI / dimethylformamide / 20 h / 60 °C

2: 88 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 12 h / Ambient temperature

3: 1.) chlorenamine, 2.) pyridine, DMAP, Et₃N, 3.) hydrazine hydrate / 2.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h, 3.) ethyleneglycol, dioxane, RT, 18 h

With pyridine; dmap; chlorenamine; hydrogen; sodium hydride; hydrazine hydrate; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01172-1

Reference yield:

: 208941-36-0
4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid benzyl ester

: 212260-31-6
4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 2-(4-hydroxy-3-iodo-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 12 h / Ambient temperature

2: 1.) chlorenamine, 2.) pyridine, DMAP, Et₃N, 3.) hydrazine hydrate / 2.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h, 3.) ethyleneglycol, dioxane, RT, 18 h

With pyridine; dmap; chlorenamine; hydrogen; hydrazine hydrate; triethylamine; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/S0040-4039(98)01172-1