208941-36-0

Upstream product

• 94-18-8 Benzyl 4-hydroxybenzoate 
• 88987-42-2 tert-butyl 5-bromovalerate 
• 2067-33-6 5-bromopentanoic acid 

Downstream Products

• 208941-37-1 4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 
• 208941-39-3 4-(4-Carboxy-butoxy)-benzoic acid 3-iodo-benzyl ester 
• 212260-31-6 4-(4-tert-Butoxycarbonyl-butoxy)-benzoic acid 2-(4-hydroxy-3-iodo-phenyl)-ethyl ester 
• 212260-29-2 4-(4-Carboxy-butoxy)-benzoic acid 2-(4-hydroxy-3-iodo-phenyl)-ethyl ester 
• 35005-21-1 4-(4-Carboxy-butoxy)-benzoic acid 

Relevant academic research and scientific papers

Application of radical chemistry to solid support synthesis

Radical cyclization of aryl iodides bound to polystyrene is described together with the trapping of the resulting radical, prior to its reduction, by allyltributyl tin.

Pd-mediated C-C and C-S bond formation on solid support: A scope and limitations study

The scope and limitations of Pd(0)-mediated coupling reactions between aromatic halides linked to a polystyrene resin and boronic acid derivatives (Suzuki coupling), aromatic and vinylic tin compounds (Stille coupling), as well as thiols are reported. For all reactions, conditions were optimized and evaluated with various reagents. In many cases, upon cleavage from the solid support, products were obtained in excellent yields. In most cases, the optimized reaction conditions are superior to those previously reported in the literature.