4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxylic acid propylamide

Base Information

Chemical Name:4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxylic acid propylamide
CAS No.:1432294-04-6
Molecular Formula:C₂₄H₃₄ClN₉O₂
Molecular Weight:516.046
Hs Code.:

Synonyms:4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxylic acid propylamide

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Chemical Property of 4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxylic acid propylamide

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Technology Process of 4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxylic acid propylamide

There total 7 articles about 4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxylic acid propylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-78-1
Propyl isocyanate

: 1432293-21-4
N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N’-(4-phenethyl-piperidin-4-yl)methylguanidine

: 1432294-04-6
4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxylic acid propylamide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 4878-36-8
3,5-diamino-6-chloro-pyrazine-2-carboxylic acid

: 1432294-04-6
4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxylic acid propylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluorormethanesulfonic acid / 1 h / Cooling with ice

1.2: 4 h / 20 °C / Cooling with ice

2.1: sodium hydroxide; water / tert-butyl methyl ether; tetrahydrofuran / 20 °C

3.1: acetonitrile / 48 h / 70 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / 20 °C

With trifluorormethanesulfonic acid; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; acetonitrile;

Reference yield:

: 1458-01-1
3,5-diamino-6-chloro-pyrazine-2-carboxylic acid methyl ester

: 1432294-04-6
4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxylic acid propylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / methanol / 3 h / Reflux

2.1: trifluorormethanesulfonic acid / 1 h / Cooling with ice

2.2: 4 h / 20 °C / Cooling with ice

3.1: sodium hydroxide; water / tert-butyl methyl ether; tetrahydrofuran / 20 °C

4.1: acetonitrile / 48 h / 70 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / 20 °C

With trifluorormethanesulfonic acid; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; acetonitrile;