4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)-phenylsulfonyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

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Chemical Name:4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)-phenylsulfonyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline
CAS No.:959996-45-3
Molecular Formula:C₂₆H₂₈F₅N₃O₃SSi
Molecular Weight:585.67
Hs Code.:

Synonyms:4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)-phenylsulfonyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

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Chemical Property of 4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)-phenylsulfonyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

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Technology Process of 4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)-phenylsulfonyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

There total 7 articles about 4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)-phenylsulfonyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 959996-44-2
N-((3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-4-(trifluoromethyl)-benzenesulfonamide

: 959996-45-3
4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)-phenylsulfonyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

Guidance literature:: With copper(l) iodide; cesium acetate; In dimethyl sulfoxide; at 120 ℃; for 2h;

Reference yield:

: 959996-42-0
3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbaldehyde

: 959996-45-3
4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)-phenylsulfonyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

2: titanium(IV) isopropylate / tetrahydrofuran / 18 h

3: tetrahydrofuran / 0.5 h / -78 °C

4: cesium acetate; copper(II) iodide; dimethyl sulfoxide / 2 h / 120 °C / Inert atmosphere

With titanium(IV) isopropylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium acetate; potassium carbonate; copper(II) iodide; dimethyl sulfoxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm301741t

Reference yield:

: 827316-45-0
3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-carboxylic acid ethyl ester

: 959996-45-3
4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)-phenylsulfonyl)-2-((2-(trimethylsilyl)ethoxy)methyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / 96 h

2.1: dimethylsulfide borane complex / tetrahydrofuran / 19 h / 0 - 50 °C

2.2: 0.5 h

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 24 h

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

5.1: titanium(IV) isopropylate / tetrahydrofuran / 18 h

6.1: tetrahydrofuran / 0.5 h / -78 °C

7.1: cesium acetate; copper(II) iodide; dimethyl sulfoxide / 2 h / 120 °C / Inert atmosphere

With titanium(IV) isopropylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; cesium acetate; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; copper(II) iodide; dimethyl sulfoxide; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm301741t