N-((3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-4-(trifluoromethyl)-benzenesulfonamide

Base Information

Chemical Name:N-((3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-4-(trifluoromethyl)-benzenesulfonamide
CAS No.:959996-44-2
Molecular Formula:C₂₆H₂₉BrF₅N₃O₃SSi
Molecular Weight:666.582
Hs Code.:

N-((3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-4-(trifluoromethyl)-benzenesulfonamide

Synonyms:N-((3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-4-(trifluoromethyl)-benzenesulfonamide

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Chemical Property of N-((3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-4-(trifluoromethyl)-benzenesulfonamide

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Technology Process of N-((3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-4-(trifluoromethyl)-benzenesulfonamide

There total 7 articles about N-((3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-4-(trifluoromethyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₃BrF₅N₃O₃SSi

: 23719-80-4
cyclopropylmagnesium bromide

: 959996-44-2
N-((3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-4-(trifluoromethyl)-benzenesulfonamide

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 0.5h; Cooling with acetone-dry ice;

Reference yield:

: 959996-42-0
3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbaldehyde

: 959996-44-2
N-((3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-4-(trifluoromethyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

2: titanium(IV) isopropylate / tetrahydrofuran / 18 h

3: tetrahydrofuran / 0.5 h / -78 °C

With titanium(IV) isopropylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm301741t

Reference yield:

: 827316-45-0
3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-carboxylic acid ethyl ester

: 959996-44-2
N-((3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-4-(trifluoromethyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / 96 h

2.1: dimethylsulfide borane complex / tetrahydrofuran / 19 h / 0 - 50 °C

2.2: 0.5 h

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 24 h

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

5.1: titanium(IV) isopropylate / tetrahydrofuran / 18 h

6.1: tetrahydrofuran / 0.5 h / -78 °C

With titanium(IV) isopropylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm301741t